Method and system for selecting drug on basis of individual protein damage information for preventing side effects of drug

a protein damage and information technology, applied in the field of personalizing drug selection, can solve problems such as difficult to find disease predicting markers, and achieve the effects of high reliability, effective personalization of drug selection, and high statistical error

Inactive Publication Date: 2018-03-08
CIPHEROME INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0014]A method and a system for personalizing drug selection on the basis of individual genome sequence variation information of the present invention can predict the individual responsiveness to a specific drug by analyzing the sequence of the exon region of a gene encoding various proteins involved in the pharmacodynamics or pharmacokinetics of a predetermined drug or drug group, and have high reliability and are widely applicable to a whole range of drugs and universal. That is, the method and the system of the present invention are universal technologies applicable to a whole range of drugs from which protein information involved in the pharmacodynamics or pharmacokinetics can be acquired with respect to metabolism, effects or side effects of drugs.
[0015]Further, conventionally, while a pharmacogenomics study needs to be conducted on each drug-gene pair, it is practically impossible to study all of the numerous drug-gene pairs because the number of pairs increases in proportion to the multiple of the number of drugs and the number of gene markers. Thus, sufficient supporting data have not yet been generated, and selection of study subjects and a difference between population groups lead to a high statistical error. However, according to the method of the present invention, results of study and analysis at a molecular level are directly applied to personalized drug treatment, and, thus, grounds of almost all of drug-gene pairs can be acquired and the method can be applied without being significantly affected by a difference between population groups.
[0016]If the method and the system of the present invention are used, it is possible to effectively personalize drug selection among one selected drug, two or more drugs in need of selection, or various comparable drugs belonging to the same drug group which can be used in a specific medical condition, and also possible to predict side effects or risks of drugs. Therefore, the method and the system of the present invention can be used to determine the order of priorities among drugs applicable to an individual or to determine whether or not to use the drugs.
[0017]Further, if new information about a drug-protein relation is found or provided, it can be easily added and applied to the method of the present invention. Thus, it is possible to provide an improved personalized drug treatment method according to further accumulation of information as results of studies.

Problems solved by technology

Meanwhile, it is not easy to find a disease predicting marker by using statistics on investigating correlation between an individual genome sequence variation and a disease.

Method used

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  • Method and system for selecting drug on basis of individual protein damage information for preventing side effects of drug
  • Method and system for selecting drug on basis of individual protein damage information for preventing side effects of drug
  • Method and system for selecting drug on basis of individual protein damage information for preventing side effects of drug

Examples

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example 1

Method for Personalizing Drug Selection with Respect to Selected One Drug (Terbutaline)

[0095]In order to provide a method for personalizing drug selection with respect to Terbutaline as one of drugs used for treating asthma, the following analysis was conducted using the method and the system of the present invention.

[0096]To be more specific, a gene sequence analysis was conducted on an individual sg01 which was healthy but determined as having a high medical risk of getting asthma since his / her mother was undergoing treatment for asthma. Gene sequence variation scores of BCHE (butyrylcholinesterase) and ADRB2 (adrenoceptor beta 2, surface) known as genes involved in the pharmacodynamics or pharmacokinetics of Terbutaline were calculated for each variant by using a SIFT algorithm, and protein damage scores and drug scores were calculated. The results thereof were as listed in Table 16 and illustrated in FIG. 3.

TABLE 16Drug nameProteinVariation information(Drug damageProteinVariatio...

example 2

Method for Personalizing Drug Selection with Respect to Two Drugs (Aspirin and Tylenol) in Need of Selection

[0099]In order to provide a method for personalizing drug selection with respect to Aspirin and Tylenol as drugs used for treating pain, the following analysis was conducted using the method and the system of the present invention.

[0100]Both of Aspirin (Acetylsalicylic acid) and Tylenol (Acetaminophen) have been widely used as painkillers, but show individual differences in responsiveness and sometimes cause severe side effects. In particular, it has been impossible to predict which of two drugs would provide a better medicinal effect or cause a more severe adverse drug reaction. Therefore, hereinafter, it will be described that the method and the system of the present invention can be used to help in making a difficult determination, which frequently occurs in clinical practice.

[0101]A gene sequence analysis was conducted on an individual sg09 which had felt discomfort when t...

example 3

Method for Personalizing Drug Selection to Assist in Selecting Highly Safe Drug Among Various Comparable Drugs Belonging to Same Drug Group (Same ATC Code Group)

[0105]In order to provide a method for personalizing drug selection to assist in selecting a drug with high safety among various comparable drugs belonging to the same drug group (same ATC code group), the following experiment was conducted using the method and the system of the present invention.

[0106]Among 22 drugs belonging to C07 beta blockers according to the internally certified ATC code, 11 drugs are specific beta blockers [C07A13], 9 drugs are non-specific beta blockers [C07AA], and two drugs are alpha and beta blockers [C07AG]. For individual genome sequence variation analysis on 14 individuals (sg01, sg02, sg03, sg04, sg05, sg07, sg09, sg11, sg12, sg13, sg14, sg16, sg17, sg19), HISEQ-2000 as an NGS (Next Generation Sequencing) device manufactured by Illumina was used to conduct a 30× whole genome sequencing. In thi...

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Abstract

The present invention relates to a method and a system for selecting a drug customized on the basis of individual protein information by using individual genome sequences. The method and the system of the present invention can predict the individual side effects or danger of a certain drug by analyzing the sequence of the exon region of a gene encoding various proteins involved in the pharmacokinetics or pharmacodynamics of a predetermined drug or drug group, and have high reliability and are widely applicable and universal.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 14 / 912,397 filed Feb. 16, 2016, which is the National Stage of International Application No. PCT / KR2014 / 007685, filed Aug. 19, 2014, which claims the benefit of KR Application No. 10-2013-0097651, filed Aug. 19, 2013, each of which is incorporated herein by reference in its entirety.TECHNICAL FIELD[0002]The present invention relates to a method and a system for personalizing drug selection on the basis of individual deleterious protein sequence variation by using individual genome sequence analysis.BACKGROUND ART[0003]With the advancement of biotechnology, at present, it is possible to predict a disease of each individual and provide personalized prevention and treatment of disease by analyzing whole genome sequence of human.[0004]Recently, as a result of comparison of individual genome sequences, it was found that different bases may be present at the same position in chromo...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G06F19/18G06F19/24C12Q1/68G16B20/20G16B20/00G16B20/40G16B40/00
CPCC12Q2600/156G06F19/24C12Q1/6883C12Q2600/106G06F19/18G16C20/30G16B20/20G16B40/00Y02A90/10G16B20/40G16B20/00C12Q1/6813C12Q1/6844
Inventor KIM, JU HANBAIK, SU YEONLEE, SOO YOUN
Owner CIPHEROME INC
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