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Cosmetic composition having high dosage form stability

a formulation and stability technology, applied in the field of cosmetic compositions, can solve the problems of degrading the absorption or texture of skin products, affecting the stability of cosmetic compositions, and affecting the use quality of products, so as to improve the stability of dosage forms, prevent the effect of reducing the texture of use, and improve the quality of products

Inactive Publication Date: 2018-06-28
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is a cosmetic composition that improves the stability of a dosage form containing kojyl methylenedioxycinnamate. This helps prevent the precipitation of crystals and other problems that can decrease the texture of the product. The increased stability also allows for a higher concentration of kojyl methylenedioxycinnamate, which has skin whitening, elasticity, and anti-aging properties. The composition can help prevent skin ageing and reduce the formation of wrinkles.

Problems solved by technology

Particularly, the skin is easily damaged by external stimuli because the skin is directly exposed to external environments.
However, the kojyl methylenedioxycinnamate is not easily dissolved in a composition due to strong crystallinity, and recrystallized or precipitated in a very short time even after dissolved in the composition, resulting in degraded skin absorption or texture in use of products.
In effect, these problems make it difficult to use the kojyl methylenedioxycinnamate as an active ingredient of a cosmetic composition even when the kojyl methylenedioxycinnamate has excellent effects.
However, the former has problems in that the solubility of the active ingredient inside a capsule is determined depending on the compatibility between polymers or the crystallinity of the polymers themselves, and a release rate of the active ingredient becomes very slow because crystals are independently formed in a polymer capsule in most cases, resulting in degraded efficiency in provision of the active ingredient.
Also, the latter still has a limitation in being commercialized because it is cumbersome and uneconomical and has no remarkable effect of improving solubility.

Method used

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  • Cosmetic composition having high dosage form stability
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Examples

Experimental program
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Effect test

experimental example 1

Precipitation Test Depending on Types of Stabilizers

[0071](1) Preparation of Emulsion Composition for Skin Care

[0072]Emulsions for skin care were prepared using the compositions presented in the following Table 1. First, components 1 to 4 were mixed, and dissolved at 70° C. to prepare an aqueous phase. Thereafter, components 5 to 11 were dissolved at 70° C. to prepare an oily phase. Subsequently, the oily phase was added to the aqueous phase, and primarily emulsified while stirring using a homomixer. Then, component 12 was added thereto to increase a viscosity of the mixture. Finally, bubbles were removed, components 13 and 14 were added thereto, and the resulting mixture was then cooled to prepare an emulsion composition. In this case, SurfMellow BBG (manufactured by Toyobo Co., Ltd.) was used as the MEL.

TABLE 1ExampleComparativeComparativeComparativeComparativeComparativeComponents (% by weight)1Example 1Example 2Example 3Example 4Example 5Aqueous phase1. Purified waterUp to 100Up...

experimental example 2

Precipitation Test Depending on Content of MEL

[0086]To check the optimal content of the MEL used as the stabilizer, emulsion compositions were prepared in the same manner as in the composition of Example 1, and precipitation tests were performed on the emulsion compositions. In this case, the content of the component was adjusted to 100% by weight by varying the content of purified water.

TABLE 3ItemsNo. 1No. 2No. 3No. 4No. 5No. 6No. 7ComponentsKojyl0.10.10.10.10.10.10.1(% by weight)methylenedioxycinnamateMEL00.250.50.7511.251.5PrecipitationImmediately afterXXXXXXXtestpreparationWeek 3◯XXXXXXWeek 10⊚▴XXXXX

[0087]Referring to Table 3, it can be seen that the crystallization of the kojyl methylenedioxycinnamate was inhibited only when the MEL was added at a content of 0.25% by weight or more, based on the total weight of the cosmetic composition. Particularly, it can be seen that the dosage form stability was maintained after 10 weeks of the preparation only when the MEL was added at a ...

experimental example 3

Precipitation Test Depending on Content Ratios of Kojyl Methylenedioxycinnamate And MEL

[0089]To check whether the crystallization occurred according to the content ratios of the kojyl methylenedioxycinnamate and MEL, emulsion compositions were prepared in the same manner as in the composition of Example 1, and precipitation tests were performed on the emulsion compositions. In this case, the content of the component was adjusted to 100% by weight by varying the content of purified water.

TABLE 4ItemsNo. 8No. 9No. 10No. 11No. 12No. 13ComponentsKojyl0.10.050.10.150.20.25(% by weight)methylenedioxycinnamateMEL00.50.50.5 0.50.5Content ratio—1:101:51:3.31:2.51:2PrecipitationImmediately afterXXXXXXtestpreparationWeek 3XXXXXXWeek 10XXXX▴▴

[0090]Referring to Table 4, it was confirmed that, when the MEL was added, the crystallization did not occur on week 3, and the crystals were observed in the tests performed on the compositions (Nos. 12 and 13) after 10 weeks of the preparation.

[0091]From t...

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Abstract

The present invention relates to a cosmetic composition using a mannosylerythritol lipid, which is a kind of glycolipid, as a stabilizer in order to prevent kojyl methylenedioxycinnamate, which is an active ingredient having various skin effects such as antiaging, whitening and antioxidation, from causing crystallization inside a dosage form. Even if the cosmetic composition according to the present invention contains a high concentration of an active ingredient, crystal precipitation does not occur in various dosage forms, and thus the functionality of the active ingredient is maximized, skin delivery is increased and the texture during use is improved.

Description

TECHNICAL FIELD[0001]The present invention relates to a cosmetic composition in which a mannosylerythritol lipid is used as a stabilizer to enhance the dosage form stability of a composition including kojyl methylenedioxycinnamate used as an active ingredient for cosmetics.BACKGROUND ART[0002]A cosmetic composition includes various active ingredients to exhibit certain effects. Particularly, the skin is easily damaged by external stimuli because the skin is directly exposed to external environments.[0003]Therefore, a number of materials have been known to prevent damage to the skin and impart various effects. For example, kojyl methylenedioxycinnamate (Trade Name: Seletinoid G™) is one of such materials, and particularly has excellent effects such as antiaging, antioxidant, and whitening effects.[0004]However, the kojyl methylenedioxycinnamate is not easily dissolved in a composition due to strong crystallinity, and recrystallized or precipitated in a very short time even after diss...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/60A61Q19/08A61Q19/02A61K8/06A61K8/49
CPCA61K8/602A61Q19/08A61Q19/02A61K8/06A61K8/4973A61K2800/52A61K8/498A61K8/60A61K8/02
Inventor KIM, YU JUNGKIM, HYEON CHUNGYOO, JAE WONKIMKIM, DO HOONPARK, SUNG II
Owner AMOREPACIFIC CORP
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