Attenuated Infectious Bronchitis Virus

a coronavirus and infectious bronchitis technology, applied in the field of attenuated coronavirus, can solve the problems of reduced egg production and quality, and death of kidney diseases
US20190022214A1Active Publication Date: 2019-01-24THE PIRBRIGHT INST
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
THE PIRBRIGHT INST
Publication Date
2019-01-24

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Abstract

The present invention provides a live, attenuated coronavirus comprising a mutation in non-structural protein nsp-3 and / or deletion of accessory proteins 3a and 3b. The coronavirus may be used as a vaccine for treating and / or preventing a disease, such as infectious bronchitis, in a subject.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to an attenuated coronavirus comprising a mutation which causes the virus to have reduced pathogenicity. The present invention also relates to the use of such a coronavirus in a vaccine to prevent and / or treat a disease.BACKGROUND TO THE INVENTION

[0002] Avian infectious bronchitis virus (IBV), the aetiological agent of infectious bronchitis (IB), is a highly infectious and contagious pathogen of domestic fowl that replicates primarily in the respiratory tract but also in epithelial cells of the gut, kidney and oviduct. IBV is a member of the Order Nidovirales, Family Coronaviridae, Subfamily Coronavirinae and Genus Gammacoronavirus; genetically very similar coronaviruses cause disease in turkeys, guinea fowl and pheasants.

[0003] Clinical signs of IB include sneezing, tracheal rales, nasal discharge and wheezing. Meat-type birds have reduced weight gain, whilst egg-laying birds lay fewer eggs and produce poor quality eggs. The r...

Claims

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