Methods for Top-Down Multiplexed Mass Spectral Analysis of Mixtures of Proteins or Polypeptides

a technology of protein and polypeptide mixtures, applied in the field of mass spectrometry, can solve the problems of limited application range of maldi-tof methods to pathogen characterization and identification, limited range of applications of maldi-tof methods, and inability to identify closely related microorganisms, etc., and achieve the effect of simplifying the mass spectrometric analysis
US20190072566A1Inactive Publication Date: 2019-03-07THERMO FINNIGAN
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Patent Information

Authority / Receiving Office
US ¡ United States
Patent Type
Applications(United States)
Current Assignee / Owner
THERMO FINNIGAN
Publication Date
2019-03-07
Estimated Expiration
Not applicable ¡ inactive patent

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Abstract

Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) and real-time data analysis methods are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge and reducing the collisional cross section.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application is a Divisional of, and claims, under 35 U.S.C. § 120, the benefit of the filing date of commonly-assigned and co-pending U.S. application Ser. No. 15 / 406,626, now U.S. Pat. No. ______, which was filed on Jan. 13, 2017 and which claims, under 35 U.S.C. § 119(e), priority to and the benefit of the filing date of commonly-assigned U.S. Provisional Application No. 62 / 278,935, filed on Jan. 14, 2016, the disclosures of which are hereby incorporated by reference in their entirety. The subject matter of this application is also related to commonly-assigned and co-pending U.S. application Ser. No. 15 / 830,439, which was filed on Dec. 4, 2017 and which is titled “Methods for Mass Spectrometry of Mixtures of Protein or Polypeptides Using Proton Transfer Reaction” and to commonly-assigned and co-pending U.S. application Ser. No. 15 / 067,727, now U.S. Pat. No. ______, which was filed on Mar. 11, 2016, the disclosures of which are here...

Claims

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