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Apparatus and method for identifying peaks in liquid chromatography/mass spectrometry data and for forming spectra and chromatograms

Chromatograms and mass spectra produced by an LC / MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC / MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix. Parameters of the peaks are determined and stored for later processing including quantitation, or simplification of chromatograms or spectra by, for example, identifying peaks associating with ions having retention times falling within a specified retention time window or having mass-to charge ratios falling within a specified mass-to-charge ratio window.
Owner:WATERS TECH CORP

Acoustic Testing Apparatus For Testing A Laminate Material And An Acoustic Testing Method For Testing A Laminate Material

An acoustic testing apparatus for testing a laminate material comprising at least one layer of a first material having a first velocity for a first vibration mode and at least one layer, adjacent to said first layer, of a second material having a velocity for a second vibration mode, approximately equal to said first velocity, said acoustic testing apparatus comprising: a first transducer for projecting an acoustic test signal onto a first layer of said at least one layer of a first material disposed in a testing zone, wherein a second transducer for receiving said test signal from said testing zone, and in that said first transducer is adapted to project said test signal at an angle so as to generate in said first layer vibrations of at least said first vibration mode, wherein said vibrations of said first vibration mode are incident on an interface with said layer of said second material under an incidence angle so as to produce in said second layer vibrations of at least said second vibration mode, so that refraction of said test signal at said interface is suppressed.
Owner:NEDERLANDSE ORG VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK (TNO)
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