61results about How to "Intuitive interpretation" patented technology

The present invention relates generally to wireless, remote, physiological monitoring in the evaluation of health and disease state specifically with respect to cardiac and pulmonary pathologies, including heart failure and sleep apnea. Personalized thresholds are used to enhance performance of classification and prediction methods by utilizing patient clinical history and past empiric sensed data, such as through an initialization period, to learn the biological variation present in each sensed individual.Data from an adherent patch undergoes disseminated processing as data is securely sent from a sensing device ultimately to a remote server. Monitoring, classification, and prediction results are hosted and made accessible through an authenticated system to members of the individual's healthcare team, family, or other caregivers.Learning algorithms are used to characterize physiological attributes and to classify a health or disease state based on an aggregate of features. Classification models and feature selection are optimized with validation algorithms.

A machine for retreading tires, including a rotary chuck on which the tire to be treated is mounted and buffing tools, in which the chuck is mounted on a first carriage guided in rails and moved by a first motor, the buffing tools are carried by a second carriage guided in rails oriented parallel to the axis of rotation of the chuck and moved by a second motor, and in which provision is made for precisely positioning the first carriage relative to the second carriage and any relative displacement between the axis of rotation of the chuck and the center of the buffing tools is contained in a single plane passing through the axis of rotation of said chuck.

A general joint component framework that is capable of exhibiting complex behaviors of joints in articulated figures is provided. A network of joint components is used to model the kinematics of a joint. A joint builder can specify parameters for each of the joint components and join the joint components to form a joint set function that captures the biomechanical dependencies between the components. The joint function has fewer inputs than the total number of possible articulations yielding both simple control and biomechanically accurate joint movement.

A Scanning Time-Resolved Emission (S-TRE) microscope or system includes an optical system configured to collect light from emissions of light generated by a device under test (DUT). A scanning system is configured to permit the emissions of light to be collected from positions across the DUT in accordance with a scan pattern. A timing photodetector is configured to detect a single photon or photons of the emissions of light from the particular positions across the DUT such that the emissions of light are correlated to the positions to create a time-dependent map of the emissions of light across the DUT.

A remote controller for use with cable or satellite provided TV program signals in which an original "over the air" TV station's real channel assignment (such as channel 38) may be instead translated to a virtual channel (such as channel 14) by the cable or satellite service provider. The viewer may enter the TV station's real channel value and the remote controller automatically converts it to the virtual channel value prior to sending it as command to the controlled device, such as a TV-set, cable box or satellite receiver. Similarly, "over the air" TV station channel numbers which have not been intermediately translated (such as 4, 5, 12, etc.) may be entered by the viewer and directly sent to the controlled device. Additionally, single digit entries may be automatically prefixed with a leading ø to reduce likelihood for an entry error by the user.

A method and device for digital multiplex PCR assays employ a microfluidic chip for performing real-time, continuous flow PCR within microchannels of the chip. A stream of sample material is introduced into each microchannel and alternating boluses of assay-specific reagents and buffer are introduced into the stream to form sequentially configured test boluses. A PCR procedure is performed on the test boluses followed by a thermal melt procedure. During the thermal melt procedure, fluorescent output is detected and fluorescence vs temperature data is collected and compared to expected normal correlations. The results, positive or negative, are converted to digital format, with positive results designated as “1” and negative results designated as “0”, or vice versa.

Chromatograms and mass spectra produced by an LC / MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC / MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix. Parameters of the peaks are determined and stored for later processing including quantitation, or simplification of chromatograms or spectra by, for example, identifying peaks associating with ions having retention times falling within a specified retention time window or having mass-to charge ratios falling within a specified mass-to-charge ratio window.

The invention provides an apparatus and methods for performing process simulation and structural analysis using a hybrid model. For example, a method of the invention automatically defines a hybrid solution domain by dividing a representation of a plastic component or mold cavity into two portions—a portion in which a simplified analysis may be conducted, and a portion in which a more complex analysis is required. The method may use as input any form of CAD data that describes the surface of a component or mold. Furthermore, the invention provides methods for simulating fluid flow within a mold cavity by automatically creating a hybrid solution domain, automatically discretizing the domain, and solving for the distribution of process variables within the solution domain.

The present invention relates generally to an adherent sensor patch for wireless and remote physiological monitoring and evaluation of health and disease state of a patient wearing the patch, and specifically with respect to cardiac and pulmonary pathologies, including heart failure and sleep apnea. Data generated by the patch, which includes a microphone sensor and other sensors, is processed by a remote server and is made accessible to caregivers and also used to manage, calibrate and control the operations of the sensors of the patch.

In one aspect, a method and apparatus for formatting code coverage data generated by performing one or more code coverage tests on a program module derived from computer code is provided, including organizing the code coverage data in a hierarchy having a plurality of tables, each of the plurality of tables configured to store information at one of successive levels of refinement, and storing, in each of the plurality of tables, code coverage information indicative of code coverage at a respective one of the successive levels of refinement. In another aspect, a data structure for storing code coverage data is provided, the data structure comprising a plurality of tables organized in a hierarchy having a plurality of levels, each of the plurality of levels corresponding to a respective construct in the programming paradigm used to structure the code, wherein each of the plurality of tables comprises a first location configured to store code coverage information at the level in the hierarchy at which the table is located.

Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) and real-time data analysis methods are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge and reducing the collisional cross section.

A device for analyzing electrophysiological data is disclosed. The device generates a signal indicative for a presence of a pulmonary vein potential component using processing means adapted for performing a stepwise analysis of the electrophysiological data. A corresponding method and computer application for installing on a device are also described.

The present invention is related to the anti-PAX8 antibodies, kits, cocktails, and use of anti-PAX8 antibodies for detection of cancer.

Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge and reducing the collisional cross section.

A method and device for digital multiplex PCR assays employ a microfluidic chip for performing real-time, continuous flow PCR within microchannels of the chip. A stream of sample material is introduced into each microchannel and alternating boluses of assay-specific reagents and buffer are introduced into the stream to form sequentially configured test boluses. A PCR procedure is performed on the test boluses followed by a thermal melt procedure. During the thermal melt procedure, fluorescent output is detected and fluorescence vs temperature data is collected and compared to expected normal correlations. The results, positive or negative, are converted to digital format, with positive results designated as “1” and negative results designated as “0”, or vice versa.

This invention represents an improvement to an equatorial sundial comprising an independent simultaneous single scale indication of both time and date as represented from a primary and secondary gnomon. This allows one unfamiliar with the physics of an equatorial sundial to with simple observation quickly assess both time and date as a singular measurement. The sundial displays conventional time measurement on a single scale transcribed on the equatorial ring from a primary gnomon aligned with the polar axis. The improvement includes a date scale transcribed on the primary gnomon that is cast a shadow from the secondary gnomon comprised of the upper equatorial ring. Since the sun maintains an essentially equivalent angle of declination throughout the day, the shadow cast by the upper equatorial ring (secondary gnomon) on the primary gnomon (containing the date scale) remains consistent in position and date can be observed at any time of the solar day.

Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge and reducing the collisional cross section.

A chemical or corrosive environment sensing system, comprising a giant magnetoresistive effect device having at least one environmentally exposed film, and a device, for sensing changes in the GMR effect device resulting from environmental exposure of the at least one environmentally exposed film. The film may be reversibly or irreversibly altered by the exposure, and is preferably nano-textured to alter a reaction rate and surface area. The sensor may be enzyme linked, that is, respond to an enzyme reaction product rather than the substrate directly. The GMR property altered and / or sensed may be, for example, a lower or upper switching field, an electrical resistance, and the GMR value. The device may be used as a sensor or as part of a control system.

The present invention is related to the anti-PAX8 antibodies, kits, cocktails, and use of anti-PAX8 antibodies for detection of cancer.

The invention provides a series of Galphaq protein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional coupling can be determined, for example, by measuring changes in intracellular IP3, or calcium. In a particular embodiment, the Galphaq protein variants can be expressed in mammalian cell lines or Xenopus oocytes, and then evaluated using calcium fluorescence imaging and electrophysiological recording.

Systems and techniques are provided in which the orientation of an ultrasonic image display is configured to match the ultrasound probe orientation for ease of interpretation. The position and the orientation of an ultrasound probe are tracked using a tracking device having one or more position and orientation sensors. The orientation of a displayed ultrasound image is automatically adjusted to reflect the position and orientation of the ultrasound probe relative to the body structure being imaged. In some embodiments, a background image (with possible landmarks) is provided based on the location and orientation of the tracked ultrasound probe.

This invention represents an improvement to an equatorial sundial comprising an independent simultaneous single scale indication of both time and date as represented from a primary and secondary gnomon. This allows one unfamiliar with the physics of an equatorial sundial to with simple observation quickly assess both time and date as a singular measurement. The sundial displays conventional time measurement on a single scale transcribed on the equatorial ring from a primary gnomon aligned with the polar axis. The improvement includes a date scale transcribed on the primary gnomon that is cast a shadow from the secondary gnomon comprised of the upper equatorial ring. Since the sun maintains an essentially equivalent angle of declination throughout the day, the shadow cast by the upper equatorial ring (secondary gnomon) on the primary gnomon (containing the date scale) remains consistent in position and date can be observed at any time of the solar day.

The sequence determination, detection, and quantification of nucleic acid molecules through sequence-specific binding (hybridization) on a solid support, specifically when Morpholinos are used as the surface-immobilized probe species in surface-based nucleic acid assays, and the assays as disclosed herein.

An acoustic testing apparatus for testing a laminate material comprising at least one layer of a first material having a first velocity for a first vibration mode and at least one layer, adjacent to said first layer, of a second material having a velocity for a second vibration mode, approximately equal to said first velocity, said acoustic testing apparatus comprising: a first transducer for projecting an acoustic test signal onto a first layer of said at least one layer of a first material disposed in a testing zone, wherein a second transducer for receiving said test signal from said testing zone, and in that said first transducer is adapted to project said test signal at an angle so as to generate in said first layer vibrations of at least said first vibration mode, wherein said vibrations of said first vibration mode are incident on an interface with said layer of said second material under an incidence angle so as to produce in said second layer vibrations of at least said second vibration mode, so that refraction of said test signal at said interface is suppressed.

An integrated circuit 2 is provided with multiple sources 12, 14, 16, 18 of trace data streams that are input via respective dedicated trace buses 20, 24 to a trace data stream combiner 22, 26. The trace data bus has trace data signal lines ATDATA for carrying trace data signals and trace source identifying signal lines ATID for carrying trace source identifying signals. A trace data stream replicator 28 may be used to replicate a single trace data stream such that the resulting multiple trace data streams may be subject to different post-replication processing / filtering as desired.

The time between heartbeats is measured over a series of such heartbeats. The time interval between two successive events is calculated and stored as a first array. The time difference between adjacent heartbeat intervals is also calculated from the first array and recorded as a differential array. The differential array is subjected to frequency analysis. First the differential array data is linearly interpolated to increase the number of data samples. The interpolated data is then subjected to a fast fourier transform (FFT) yielding a power spectrum. Characteristic frequency ranges are then integrated and the resulting frequency domain spectrum(s) are analyzed for dominant frequency characteristics.