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Cannabinoid lozenge formulation

a technology of cannabinoids and formulations, applied in the direction of pill delivery, organic active ingredients, pharmaceutical non-active ingredients, etc., can solve the problems of unacceptable medical use of cannabis, unsatisfactory effects of smoking cannabis, and general health problems, so as to enhance the release of cannabinoids, enhance the release of one or more cannabinoids, and enhance the effect of cannabinoids

Active Publication Date: 2020-10-22
NORDICCAN AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a lozenge formulation that combines the beneficial properties of cannabinoids with the sensory properties of a good product. The use of a master granule component in combination with an extragranular component improves the delivery of the formulation. Water-soluble cannabinoids are particularly useful for enhancing the release of the formulation.

Problems solved by technology

However, there are health concerns for this mode of administration.
Furthermore, many patients find the act of smoking unappealing, as well as being generally unhealthy.
For these reasons, smoking cannabis is not acceptable as a medical means of administration.
These formulations were found to be of varying effectiveness in delivering the active agent to the lungs and compliance was an issue even with proper training on the use of inhalation devices.
However, cannabinoids are highly lipophilic, meaning that they are soluble in lipids and some organic solvents while being substantially insoluble or only sparsely soluble in water.
Some of these solvents are pharmaceutically unacceptable, and the pharmaceutically acceptable solvents need to be used in high concentrations to produce solutions.
One of the challenges with lozenges as a delivery vehicle of cannabinoids is that cannabinoids tend to be associated with off-notes during administration due to the specific physiochemical properties of the compounds.
The taste masking challenge is more profound when a higher release of cannabinoids are delivered by such lozenges.
If off-notes are the predominant sensation during administration, convenience may be affected and even more critically, the delivery of cannabinoids may also be affected.
Saliva production may be suppressed, and the delivery vehicle may not be handled correctly.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0238]Component with CBD Extract 50%

[0239]CBD extract with a 50% content of CBD provided by CBDepot (batch number CSFF 2018 / 5) was preheated to around 60° C. for around 0.5 to 1 hour until the extract was in liquid form. The extract had, beside cannabinoids, a content of fatty acids, glycerol, waxes, terpenes and flavonoids. After the preheating process, the extract was applied as a thin layer on top of one or more sugar alcohol particles. After mixing until CBD was homogeneously distributed in the one or more sugar alcohol particles, the mixture was sieved through a 1400 microns sieve.

example 2

[0240]Component with CBD Extract 10%

[0241]CBD extract with a 10% content of CBD provided by Medical Hemp (batch number MH131B Gold), was preheated to around 60° C. for around 0.5 to 1 hour until the extract was in liquid form. The extract had, beside cannabinoids, a content of fatty acids, glycerol, waxes, terpenes and flavonoids. After the preheating process, the extract was applied as a thin layer on top of one or more sugar alcohol particles. After mixing until CBD was homogeneously distributed in the one or more sugar alcohol particles, the mixture was sieved through a 1400 microns sieve.

example 3

[0242]Component with CBD Isolate with a Solvent

[0243]CBD isolate from cannabis plant tissues (phytocannabinoid) with a 98.5% content of CBD provided by Medical Hemp (batch number MH18212) was dissolved in a 96% ethanol solution. The ratio between the CBD isolate and ethanol was 1:1. Once CBD was dissolved in ethanol, the CBD isolate was applied in a premix with one or more sugar alcohol particles. After mixing until CBD was homogeneously distributed in the one or more sugar alcohol particles, the mixture was sieved through a 1400 microns sieve.

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Abstract

The present invention relates to a lozenge composition for controlled release of cannabinoids comprising; i) a master granule component comprising one or more solid particles and one or more cannabinoids reversibly associated with the one or more solid particles; and ii) an extragranular component blended with the master granule component comprising one or more extragranular sugar alcohols.

Description

FIELD OF THE INVENTION[0001]The invention relates to the field of cannabinoids and alleviation or treatment of a condition with one or more cannabinoids. In particular, the invention relates to lozenges for oral administration of one or more cannabinoids. More specifically, the invention relates to formulation designs that are particularly useful for administration of one or more cannabinoids.BACKGROUND OF THE INVENTION[0002]Cannabinoid delivery methods have been the attention of more and more interest in recent years. Lung delivery is most commonly achieved by smoking cannabis. However, there are health concerns for this mode of administration. Cannabis smoke carries even more tars and other particulate matter than tobacco. Furthermore, many patients find the act of smoking unappealing, as well as being generally unhealthy. For these reasons, smoking cannabis is not acceptable as a medical means of administration.[0003]Cannabinoids are a group of chemicals found in Cannabis sativa,...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K9/00A61K31/05A61K47/38A61K47/26A61K47/40A61K47/02
CPCA61K9/0056A61K47/38A61K47/02A61K31/352A61K31/05A61K47/26A61K47/40A61K9/2018
Inventor BRUUN, HEIDI ZIEGLERBOESEN, DORTHE SCHACKINGERERIKSEN, ANE
Owner NORDICCAN AS