Methods and systems for the detection and removal of pathogens from blood

Pending Publication Date: 2021-11-18
STICHTING SANQUIN BLOEDVOORZIENING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a filter that can remove pathogens from blood or blood products. The filter works by binding to the pathogens, rather than the host cells that may also carry the pathogens. This means that the filter can remove any type of pathogen, and can be used with different types of blood or blood components. The filter can be made from inexpensive polymers and can be returned to a patient without needing to remove other blood components. The method also reduces the load of pathogens in the blood, which may help to prevent sepsis. Overall, the filter has a dual effect of removing pathogens and reducing the inflammatory response in the body.

Problems solved by technology

It results from an individual's immune system response and is associated with fever or hypothermia, rapid breathing, elevated heart rate, and / or edema and may lead to cardiovascular collapse and multiple organ failure.
Sepsis is a major cause of morbidity and mortality in intensive care units, where it has a mortality rate of from 30 to 60%.
Sepsis occurs when an individual's immune system is unable to efficiently counteract an infection and remove pathogens from the blood stream resulting in an uncontrolled systemic inflammatory response.
Current medical treatment of sepsis mainly relies on antibiotics which is generally unsuccessful.
A disadvantage of such method is that it is expensive, in part due to the need of donor plasma, and non-selective.
The removal of host defence components may result in a risk of infection.
In addition, there is a risk of an immune response of the host's immune system to donor plasma or its components.
These methods are, however, costly due to the use of large amounts of specific antibodies and would need to be combined so that both pathogenic toxins and inflammatory cytokines are removed in order to sufficiently counteract sepsis.
In addition, a further disadvantage of such methods is that pathogens are not removed from the blood but returned to the patient.
However, a major disadvantage of targeting the pathogen is that it is specific for one or a group of pathogens because the pathogen are captured using a ligand that is able to bind a specific pathogen.
This inevitably also means that it is necessary to diagnose the pathogen causing the infection before pathogen removal by apheresis can be performed.
Since immediate treatment is essential in sepsis, diagnosis of the infecting pathogen may cause an unacceptable delay.

Method used

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  • Methods and systems for the detection and removal of pathogens from blood
  • Methods and systems for the detection and removal of pathogens from blood
  • Methods and systems for the detection and removal of pathogens from blood

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Experimental program
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first embodiment

[0110]FIG. 6 shows a schematic view of a system according to an aspect of the invention;

second embodiment

[0111]FIG. 7 shows a schematic view of a system according to an aspect of the invention;

third embodiment

[0112]FIG. 8 shows a schematic view of a system according to an aspect of the invention;

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Abstract

The invention relates to methods and systems for removal of pathogens from blood or blood products. The invention further relates to methods and systems for treatment and diagnosis of infection in the blood and / or sepsis in a patient in need thereof.

Description

RELATED APPLICATIONS[0001]This application is a Divisional Application of U.S. Ser. No. 15 / 546,403, filed Jul. 26, 2017, which is the U.S. National Stage of International Patent Application No. PCT / NL2016 / 050058, filed Jan. 26, 2016, which claims the priority of European patent application EP 15152486.5 filed Jan. 26, 2015. The entire content of each of these applications is incorporated herein by reference in entirety.FIELD OF THE INVENTION[0002]The invention relates to the field of biology and medicine. In particular, the invention relates to methods and systems for the detection and removal of pathogens from blood or a blood component.BACKGROUND OF THE INVENTION[0003]Sepsis is a severe systemic inflammatory response to an infection. It results from an individual's immune system response and is associated with fever or hypothermia, rapid breathing, elevated heart rate, and / or edema and may lead to cardiovascular collapse and multiple organ failure. The pathophysiology of sepsis is...

Claims

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Application Information

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IPC IPC(8): A61M1/36G01N33/569G01N33/555C12Q1/04C12Q1/10C12Q1/18G01N15/14G01N33/50
CPCA61M1/3633G01N2015/1006A61M1/362A61M1/3679G01N33/569G01N33/555A61M1/3675C12Q1/04C12Q1/10C12Q1/18G01N15/14G01N33/5091A61M2202/0429A61M2205/75G01N2800/26A61M1/3672A61M1/3693A61M1/3623Y02A50/30
InventorVAN BRUGGEN, ROBINVISSER, ASTRID
OwnerSTICHTING SANQUIN BLOEDVOORZIENING