Methods and compositions for prevention and treatment of restenosis with non-steroidal anti-inflammatory drugs

Abstract

Methods and compositions for the prevention and / or treatment of vascular restenosis, the methods comprising administering to individuals in need thereof, an effective amount of a non-steroidal anti-inflammatory drug alone or in combination with other conventional therapies to induce apoptosis, reduce proliferation, induce quiescence, inhibit cell migration, or influence cell differentiation of the cells in the vascular wall and or / induce hypolipidemia.

Description

1. INTRODUCTIONThe present invention relates to methods and compositions for the prevention and treatment of cardiovascular disease, specifically, but not limited to, restenosis and arterial inflammation with the administration of non-steroidal anti-inflammatory drugs (NSAIDs). The present invention relates to methods and compositions for preventing and / or treating restenosis in mammals, by inducing or stimulating apoptosis, reducing proliferation, inducing quiescence, inhibiting cell migration, altering argiogenesis, altering extracellular matrix formation, or influencing cell differentiation of the cells of the vessel wall that contribute to arterial lesions. In particular, the methods and compositions of the invention are useful in the stimulation of cell death and / or the inhibition of the robust response to arterial injury by inhibition of the proliferation or migration of vascular cells or other target cells that contribute to arterial lesions formation.2. BACKGROUND OF THE INV...

AI Technical Summary

Benefits of technology

NSAIDs effectively reduce vascular cell proliferation and inflammation, thereby lowering the incidence of restenosis and atherosclerotic lesion formation, as demonstrated in animal models, offering a promising approach to managing cardiovascular disease recurrence post-angioplasty and other vascular interventions.

Problems solved by technology

The advanced lesions of atherosclerosis may occlude the artery affected, and result from an excessive inflammatory response to different forms of injury.

The failure rate after these approaches due to restenosis, in which the occlusions recur and often become even worse, is very high (30-50%).

In fact, recent figures showed 30% of angioplasty patients require a revascularization procedure within one year of their original procedure due to restenosis, resulting in approximately two billion dollars in health care charges on top of the initial costs for surgery.

However, such approaches cannot identify the full range of gene products that are involved in the disease process; and much less identify those which may serve as therapeutic targets for prevention and treatment of restenosis and inflammatory proliferative diseases.

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