The invention discloses a sustainable grassland desertification control method. The method comprises the following steps: carrying out closing, concretely enclosing a desertification grassland area, and banning grazing; supplying water, concretely digging gullies through nearby water systems, and laying a plurality of strip-shaped water collecting strips; carrying out conditioning, concretely carrying out spraying conditioning on the desertification grassland by using a soil conditioner; carrying out sowing, concretely sowing seeds of drought-resistant plants, mesophyte herbaceous plants and pasture grass; carrying out irrigation, concretely carrying out irrigation for once every 1-2 months after irrigation is carried out for the first time in spring; carrying out reseeding, concretely carrying reseeding by using seeds of the drought-resistant plants, mesophyte herbaceous plants and pasture grass according to conditions; and carrying out recuperation, concretely carrying out recuperation and rehabilitation, sowing seeds of the mesophyte herbaceous plants, and carrying out irrigation and reseeding. According to the sustainable grassland desertification control method, hydrological and soil foundations are constructed on the basis of ecology, and biotic communities are constructed on the hydrological and soil foundations, so that a concept of sustainable development is implemented, and an inestimable profound influence is achieved on treatment of grassland desertification.