The invention discloses a combined formula for adjusting the mucus layer barrier on the surface of digestive tracts and respiratory tracts, which belongs to the field of medicines. The present invention uses salvia miltiorrhiza, threonine, serine, cysteine, cystine and proline as a combined formula. Salvia miltiorrhiza has the effect of enhancing the blood supply and oxygen supply of the human body; threonine, serine, cysteine, and proline are the main components of mucin. The combination formula of the present invention provides nutrients, oxygen and raw materials for mucous cells such as goblet cells and mucus glands in digestive tracts and respiratory tracts, and for the generation, renewal, repair and secretion of mucin; Barrier, preventing antigens from approaching, contacting, adhering and entering the digestive tract and respiratory tract tissue, blocking abnormal immune response, terminating inflammation, repairing digestive tract and respiratory tract tissue, effective combination formula for preventing and treating digestive system and respiratory system diseases .