Method for preparing Chinese medicine preparation for treating chronic conjestive heart-failure

A technology for heart failure and traditional Chinese medicine preparations, which is applied in the field of preparation of traditional Chinese medicine preparations to achieve the effects of improving the integral of symptoms of kidney deficiency, inhibiting cardiac remodeling and high yield

Active Publication Date: 2007-08-29
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And there is no ideal treatment of chronic heart failure oral Chinese medicine (including natural medicine) listed both at home and abroad at present.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of Xinsheng granules

[0023] 1. Take 2.5 kg of antler gum and crush it, pass through an 80 mesh sieve, and set aside.

[0024] 2. Take 25kg of Epimedium, 20kg of Ligustrum lucidum, 25kg of Psoralen, 15kg of Cornus, 10kg of Tangerine Peel, add 10 times the amount of water each time, and decoc three times at 90℃, the first and second times each for 1 hour, the third After half an hour, filter, combine three decoctions, concentrate to a relative density of 1.04-1.05 (room temperature), centrifuge at 16000 rps, take the supernatant and concentrate to a relative density of 1.10-1.14 (90°C), add appropriate amount of dextrin, The extract powder is spray-dried, and then antler gum powder, appropriate amount of dextrin and correctives are added, mixed, granulated with 85% ethanol containing 2% PVP, and dried to obtain 36 kg of granules, sizing and packaging. The content of icariin was 2.22mg / g and the content of psoralen was 0.76mg / g.

Embodiment 2

[0025] Example 2 Preparation of Xinsheng Granules

[0026] 1. Take 3kg of antler gum and smash it through an 80-mesh sieve for use.

[0027] 2. Epimedium 30kg, Ligustrum lucidum 30kg, Psoralen 20kg, Cornus 15kg, Tangerine peel 15kg, add water at 100℃ to extract, a total of three times, the first and second time each for 1 hour, the third time for half an hour, filter, Combine the three decoctions, centrifuge at 14000 rps, and concentrate the supernatant to a relative density of 1.10 to 1.14 (90°C). Spray dry to obtain extract powder, add antler gum powder and appropriate amount of dextrin, mix, and dry-extrusion granulation. Get 30kg of pellets and pack them. The content of icariin was 3.58mg / g and psoralen was 0.82mg / g.

Embodiment 3

[0028] Example 3 Preparation of Xinsheng Granules

[0029] 1. Take 2.2 kg of antler gum and smash it through a 100-mesh sieve for use.

[0030] 2. Take 25kg of Epimedium, 22kg of Ligustrum lucidum, 18kg of psoralen, 13kg of cornus, 13kg of dried tangerine peel, add water to 100℃ and decoct twice, 1 hour each time, filter, combine the second decoction, and concentrate to an appropriate amount. Centrifuge at 16000rps at a high speed, take the supernatant and concentrate to a relative density of 1.12 (90℃), add an appropriate amount of dextrin, mix, and spray dry to obtain an extract powder, add antler gum powder and an appropriate amount of dextrin, and fluidize granulation to obtain granules 30kg, divided into packages. The content of icariin was 2.82mg / g and the content of psoralen was 0.70mg / g.

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Abstract

The Chinese medicine preparation for treating chronic heart failure is prepared with the Chinese medicinal materials antler glue or antler tablet, epimedium, privet fruit, malaytea scurfpea fruit, dogwood and dried orange peel in certain proportion. The preparation process includes decocting the medicine materials except antler glue or antler tablet, high speed centrifuging to eliminate impurity, concentrating the supernatant, spray drying to obtain extractum powder, adding antler powder and supplementary material, and preparing oral preparation via conventional process. The Chinese medicine preparation has high active component content, determined curative effect and easy preparation, and is suitable for industrial production.

Description

Technical field [0001] The invention relates to the field of traditional Chinese medicine. Specifically, it relates to a preparation method of a traditional Chinese medicine preparation for treating chronic congestive heart failure. Background technique [0002] Congestive heart failure (CHF) is a syndrome that will eventually occur in a variety of heart diseases. According to Framingham research data, there are more than 10 million heart failure patients in my country, with an annual incidence of about 3 to 4‰. A common and frequently-occurring species. At present, the commonly used drugs in clinical practice are diuretics, digitalis cardiac glycosides and vasodilators, but their effects are incomplete or have varying degrees of toxicity and side effects. There is a lack of traditional Chinese medicines used to fight chronic heart failure. Therefore, as a market demand, new Chinese medicines related to anti-heart failure will have broad development prospects and a larger market....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61K36/487A61K36/40A61K36/296A61K36/185A61K35/32A61P9/04
Inventor 徐德生刘力胡婉英罗月琴唐岚
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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