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Micronize diosmin and hesperidine composition suppository

A technology of diosmin and hesperidin, which is applied in the field of medicine, can solve the problems that the blood drug concentration cannot be maintained within the therapeutic range, the bioavailability is low, and cannot be taken on time, so as to avoid the first-pass effect, reduce toxicity and Side effects and the effect of reducing the number of medications

Inactive Publication Date: 2008-12-24
刘展欣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Currently, diosmin and hesperidin mixture tablets are on the market, which are clinically used as hemorrhoid medicine, antiphlebitis and antivaricose veins, but it has a first-pass effect, which leads to a large loss of flavonoids and low bioavailability. Lead to taking large doses and taking more frequently
It is inconvenient for patients who are busy with work to take medication, and often cannot take it on time, resulting in blood drug concentration that cannot be maintained within the therapeutic range
And the dosage of taking is big, causes the raising of cost, also brings certain economic burden to patient

Method used

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  • Micronize diosmin and hesperidine composition suppository

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 A micronized diosmin and hesperidin suppository

[0042] Diosmin 45g

[0043] and hesperidin 5g

[0044] PEG 4000 80g

[0045] PEG 6000 60g

[0046] Under high airflow, micronize diosmin and hesperidin to obtain powders with an average particle size of about 5 μm, heat and melt PEG4000 and PEG6000, mix well, and add the micronized mixture of diosmin and hesperidin , add and stir, pour into a suppository mold coated with lubricant, condense, and make 100 suppositories.

Embodiment 2

[0047] Example 2 A micronized diosmin and hesperidin suppository

[0048] Diosmin 42g

[0049] Hesperidin 8g

[0050] Sodium Benzoate 10mg

[0051] Semi-synthetic fatty acid glycerides 150g

[0052] Under high airflow, micronize diosmin and hesperidin to obtain powder particles with an average particle size of about 2.5 μm, mix the micronized diosmin and hesperidin with sodium benzoate evenly to obtain a mixed powder, and Semi-synthetic fatty acid glycerides are melted on a water bath, and the mixed powder is added to the melted matrix, and stirred evenly to form a uniform suspension. Pour it into the suppository mold, scrape off the excess material after cooling, and demould, and then make 100 suppositories.

[0053] The effect of the micronized diosmin and hesperidin composition suppository of the present invention is illustrated by experiments below:

[0054] The pharmacokinetic characteristics and comparison of the micronized diosmin and hesperidin composition supposi...

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Abstract

A composite suppository for treating pile, phlebitis and phlebeurysma is prepared from micro-granular diosmin and hesperidin, matrix for suppository and additive.

Description

field of invention [0001] The invention relates to the technical field of medicine, in particular the invention relates to a micronized diosmin and hesperidin composition suppository, which is clinically used as hemorrhoid medicine, antiphlebitis and antivaricose veins. Background of the invention [0002] Hemorrhoids, phlebitis, and varicose veins are all common frequently-occurring diseases, which are caused by various complex factors such as abnormal hemorheology and poor microcirculation. At present, the treatment methods for this disease are divided into surgical treatment and drug treatment. Although surgical treatment is relatively thorough, it is painful for patients, and it is difficult to avoid recurrence elsewhere, and it may also leave certain sequelae such as anal stenosis. Therefore, patients generally adopt drug treatment, and the commonly used ones are external medicines such as Huazhi suppository, hemorrhoid ointment, etc., and their effects are detumescence...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/02A61P9/14
Inventor 刘展欣
Owner 刘展欣
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