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Dripping pills of 'Da Yuan Yin' and preparation method thereof

A technology of dropping pills and extracts, applied in the directions of pill delivery, pharmaceutical formulations, plant raw materials, etc., can solve the problems of not being able to achieve rapid onset of action, delaying the best time, and reducing blood drug concentration, and achieving the goal of being beneficial to cleanliness and labor. The effect of protection, low cost and high degree of automation

Inactive Publication Date: 2008-12-31
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The traditional dosage form of "Dayuan Decoction" is water decoction. In order to better exert the clinical curative effect of Dayuan Decoction, medical workers have conducted a lot of research on this classic prescription, mainly focusing on its clinical pharmacological effects. There is no report on dosage form transformation. Currently, the existing dosage forms include Dayuan Pills, which are large honey pills. Due to the sudden onset of fever and fierce onset caused by SARS and other respiratory viruses, the traditional method of administration cannot achieve rapid onset of effect. .Traditional water decoction, which passes through the gastrointestinal tract after oral administration, has a "hepatic first-pass effect", and some active ingredients are decomposed, which reduces the blood concentration of the drug and reduces the curative effect. It is also inconvenient to use, especially for critically ill patients. the best time to administer the drug.

Method used

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  • Dripping pills of 'Da Yuan Yin' and preparation method thereof
  • Dripping pills of 'Da Yuan Yin' and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] First, take the purified medicinal materials such as betel nut, magnolia officinalis, grass fruit, scutellaria baicalensis, white peony root, licorice, etc., and the magnolia officinalis medicinal materials are crushed into coarse powder.

[0069] (1) Weigh 300 g of Magnolia officinalis medicinal material coarse powder, add 10 times the amount of 85% ethanol, cold soak 3 times, each time for 10 hours, filter, combine the filtrate, recover ethanol under reduced pressure until no alcohol smell, concentrate into extractum, Magnolia officinalis extract.

[0070] (2) Take 150g of grass nuts and soak them in water overnight, extract by steam distillation for 7 hours, collect the volatile oil, and get the grass fruit extract.

[0071] (3) Take 600g of betel nut, 300g of Anemarrhena, 300g of peony, 300g of baicalin, and 150g of licorice, decoct in water for 3 times, each time for 1 hour, filter, combine the filtrate, concentrate, and add 95% ethanol to precipitate when concentr...

Embodiment 2

[0074] Take the purified medicinal materials such as betel nut, magnolia bark, grass fruit, scutellaria baicalensis, white peony root, licorice, etc., magnolia bark medicinal material is crushed into coarse powder, weigh 300g of magnolia bark medicinal material coarse powder, add 10 times the amount of 60% ethanol, and cold soak 3 times , 15 hours each time, filter, combine the filtrates, recover ethanol under reduced pressure until there is no alcohol smell, concentrate it into an extract, and obtain Magnolia officinalis extract. Take 150 g of grass nuts and add 10 times the amount of water, soak overnight, and extract by steam distillation , collect volatile oil, and get Caoguo extract. Take 600g of betel nut, 300g of Anemarrhena, 300g of peony, 300g of skullcap, 150g of licorice, add 10 times the amount of water, decoct in water for 3 times, each time for 1 hour, filter, combine the filtrate, and concentrate , when concentrated to 1.10-1.15, add 95% ethanol to ethanol precip...

Embodiment 3

[0076] Take the purified medicinal materials such as betel nut, magnolia officinalis, grass fruit, scutellaria baicalensis, white peony root, licorice, etc., magnolia officinalis medicinal materials are crushed into coarse powder, weigh 300g of magnolia bark medicinal material coarse powder, add 10 times the amount of 45% ethanol, and cold soak 3 times , 20 hours each time, filter, combine the filtrates, recover ethanol under reduced pressure until there is no alcohol smell, concentrate it into an extract, and obtain Magnolia officinalis extract. Take 150 g of grass nuts and add 10 times the amount of water, soak overnight, and extract by steam distillation , collect the volatile oil to get the grass fruit extract. Take 600g betel nut, 300g anemarrhena, 300g peony, 300g skullcap, 150g licorice, add 10 times the amount of water, decoct 3 times, 1 hour each time, filter, combine the filtrate, concentrate, add 95% when concentrated to 1.10-1.15 Ethanol precipitation, alcohol prec...

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Abstract

The invention discloses a traditional Chinese medicine dripping pill for treating fever caused by respiratory viruses and a preparation method thereof. It is extracted and refined from betel nut, magnolia officinalis, grass fruit, scutellaria baicalensis, white peony root, and licorice to obtain an extract with a high content of active ingredients. The extract is added to the molten matrix, mixed evenly, and dripped into a drop pill. Dry and serve. The weight-number ratio of each component is: 20-60 parts of Dayuanyin extract, 20-120 parts of matrix, and 0-5 parts of other auxiliary materials. The Dayuanyin dripping pill of the present invention is used for treating fever caused by respiratory viruses, is a solid dispersion dosage form, and is used as a first-aid dosage form, has quick onset, strong effect, high bioavailability and is convenient to use. The dropping pill process has simple equipment, convenient operation, high degree of automation, low cost and easy quality control.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine dripping pill for treating fever caused by respiratory virus and its preparation method. Specifically, it is a medicine containing betel nut, magnolia officinalis, grass fruit, scutellaria baicalensis, white peony root, licorice ("Dayuan Decoction Prescription"), etc. Traditional Chinese medicine dripping pills made of extracts and bases and preparation methods thereof. Background technique [0002] Respiratory viruses often lead to severe epidemic diseases. The danger of atypical pneumonia (SARS) has attracted great attention from all over the world. It will continue to endanger human health. The most obvious sign of this type of disease is fever. Colds and fever caused by other respiratory viruses are a high-risk species. The new drug "Dayuan Dropping Pills" developed on the basis of traditional Chinese medicine theory The confrontation has obvious effect. [0003] According to the feb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8964A61K36/889A61K36/575A61K36/539A61K36/484A61K9/20A61P31/12A61P31/14A61P11/00
Inventor 张铁军廖茂梁薛艳
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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