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Ultra-high-molecular-weight-polyethylene and drug complexes artificial joint material and preparation method thereof, and artificial joint prepared therefrom

An ultra-high molecular weight, artificial joint technology, applied in artificial joint materials and its preparation, and in the field of hip joints, can solve problems such as artificial joint prosthesis loosening, and achieve the goal of overcoming low bioavailability, inhibition of differentiation and activity, and obvious effects Effect

Inactive Publication Date: 2009-04-01
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two fixation methods are all due to joint movement, wear and other factors that cause the artificial joint prosthesis to loosen.

Method used

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  • Ultra-high-molecular-weight-polyethylene and drug complexes artificial joint material and preparation method thereof, and artificial joint prepared therefrom
  • Ultra-high-molecular-weight-polyethylene and drug complexes artificial joint material and preparation method thereof, and artificial joint prepared therefrom

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Add 0.5 parts of estradiol to 99.5 parts of ultra-high molecular weight polyethylene powder with a diameter of 60 μm to 270 μm and a molecular weight of 2.50±500,000, and mix evenly to obtain a powdery composite artificial joint material.

Embodiment 2

[0028] Take 10 parts of estradiol and add it to its solvent—acetone, then add 90 parts of ultra-high molecular weight polyethylene powder with a molecular weight of 4.5 million ± 500,000 and a diameter of 60 μm to 270 μm, mix evenly to form a suspension, and vacuum dry it. A composite material in powder form is obtained.

Embodiment 3

[0030] Take 6 parts of estradiol alendronate sodium and add it into distilled water to dissolve, then add 94 parts of ultra-high molecular weight polyethylene powder with a molecular weight of 3.50±500,000 and a diameter of 60 μm to 270 μm, and mix evenly to form a suspension. After vacuum drying, a uniformly dispersed mixture is made, and then placed in a hot press mold for hot pressing. After four stages of pre-pressing, heating, heat preservation, and cooling, the mold is taken out to obtain a shaped solid composite material.

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Abstract

The invention disclosed a kind of super high molecular weight polyethylene / medicine compounded artificial joint as well as the preparing method and the prepared coax joint. The materials of the invention include 99.5-90 shares (by weight) of super high molecular weight polyethylene and 0.5-10 shares of medicine that can restrain osteolysis. After implanting the invention in human bodies, it can prevent the ostelysis of artificial hip joint and total knee prosthesis under common conditions; it can also prevent the cinch of prosth, prolong the service life of artificial joints, and ease the pain and burden of patients.

Description

technical field [0001] The invention relates to a medical biological material, in particular to an artificial joint material, its preparation method and application, and a hip joint made therefrom. Background technique [0002] The artificial joint replacement made of ultra-high molecular weight polyethylene as one of the main materials has been successfully applied clinically, providing the possibility to improve the quality of life of many patients with bone and joint diseases. In developed countries such as Europe and the United States, the number of artificial hip and knee replacements has exceeded 500,000 per year. There are more than 30,000 patients receiving artificial joint implantation in China every year. After decades of hard work, artificial joints have been greatly improved in terms of material modification, fixation methods and mechanical design. However, the service life of artificial joints is always very limited. At present, a large number of artificial hi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/16A61L27/40A61F2/30
CPCA61F2/34A61F2002/30001
Inventor 屈树新刘爱芹朱旻昊周仲荣翁杰
Owner SOUTHWEST JIAOTONG UNIV
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