pH sensitive polymer and process for preparation thereof
A polymer and sensitive technology, applied in the field of preparation of the polymer, can solve the problems of no reports
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Embodiment 1
[0072] Synthesis of pH-sensitive polymers by bulk polymerization. 35% w / w methyl methacrylate, 30% w / w vinylpyridine and 35% w / w hydroxyethyl methacrylate monomers were mixed together and an azo initiator (1 Azobisisobutyronitrile in % w / w total amount of monomer). The reaction mixture was purged with nitrogen to provide an inert atmosphere. Polymerization was carried out by heating the reaction mixture to 65°C for 18 hours. The polymer thus synthesized was recovered by dissolving in a solvent including dichloromethane and methanol (1:1) and precipitating in a non-solvent. The non-solvent used was diethyl ether. The polymer was dried under vacuum at 27°C.
Embodiment 2
[0074] Synthesis of pH-sensitive polymers by bulk polymerization. 35% w / w methyl methacrylate, 30% w / w vinylpyridine and 35% w / w butyl acrylate monomers were mixed together and an azo initiator (1% w / w mono volume of azobisisobutyronitrile). The reaction mixture was purged with nitrogen to provide an inert atmosphere. Polymerization was carried out by heating the reaction mixture to 65°C for 18 hours. The polymer thus synthesized was recovered by dissolving in a solvent including dichloromethane and methanol (1:1) and precipitating in a non-solvent. The non-solvent used was diethyl ether. The polymer was dried under vacuum at 27°C.
[0075] Table 1
[0076] Polymer swelling / solubility properties in acidic buffer pH 1.2
[0077] S.NO polymer composition Measured properties 1
Methyl Methacrylate 35% w / w
Hydroxyethyl Methacrylate 35% w / w
Vinylpyridine 30% w / w The polymer film begins to dissolve immediately
Solution, the whole film is in ...
Embodiment 3
[0082] Synthesis of pH-sensitive polymers by solution polymerization. The hydrophobic monomer, basic monomer and optional hydrophilic monomer are dissolved in dimethylformamide solvent. An azo initiator (azobisisobutyronitrile) was added to the monomer solution in dimethylformamide. The reaction mixture was purged with nitrogen to provide an inert atmosphere. Polymerization was carried out by heating the reaction mixture to 65°C for 18 hours. The polymer thus synthesized was recovered by dissolving in a solvent comprising dichloromethane and methanol 1:1 and precipitating in a non-solvent diethyl ether. The polymer was dried under vacuum at 27°C. Polymers are characterized by molecular weight. The molecular weight of the synthesized polymer was determined by Waters Gel Permeation Chromatography with polystyrene standards (Polysciences, USA) as reference, using a polystyrene type cross-linked copolymer (Styragel) column. In Table 3 the monomer composition and molecular wei...
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