Aweto micropowder tablet and preparation method thereof

Abstract

The present invention relates to a cordyceps sinensis powder tablet and a preparation method thereof, which pertains to the field of medicines and health products. The technical problem the present invention aims at providing a tablet containing cordyceps sinensis medicinal powder and no auxiliary material; the appearance, shape and harness of the tablet is consistent with the tablet quality standard. The cordyceps sinensis powder tablet only adopts cordyceps sinensis powder with the water content of 8 to 18 percent and the granule diameter of 1 to 150mum; no auxiliary material is added in the preparation process and the cordyceps sinensis powder is the only component. The aim of direct tablet forming can be achieved by controlling the water of the powder or by the process of second tabletting or dry granule tabletting. The process ensures that the tablet appearance is good; pockmark surface rate and fracture rate are low; tablet harness, disintegration rate and friability are consistent with the tablet quality requirement; the harness can also ensure that the tablet can not fracture in the preparation process when coating and film covering is carried out in the later stage.

Description

technical field [0001] The invention relates to micropowder tablets of Cordyceps sinensis and a preparation method thereof, belonging to the field of medicine and health care products. Background technique [0002] Usually, when preparing tablets, those skilled in the art must first select appropriate excipients according to the properties of the drug and the requirements of clinical medication, and then mix and process them to make them have good fluidity and compressibility. (Chinese Medicine Pharmaceutics, China Press of Traditional Chinese Medicine, first edition in January 2003, p411, penultimate paragraph 2), the choice of excipients is extremely important during direct compression, the most important of which are fillers and binders, They are the key to tableting. The excipients in the direct compression tablet prescription, especially the role of fillers and binders, are more important in the wet granulation method (Chinese Medicine Pharmaceutics, China Traditional ...

AI Technical Summary

Problems solved by technology

However, the surface tension of micropowder with a particle size of 1-150 μm is very large, and the gaps between the powders are large. Usually, it is difficult for those skilled in the art to directly compress or granulate it, and it is necessary to add auxiliary materials to improve its fluidity and compressibility. tablet

And in the process of compressing tablets with Cordyceps micropowder, it is found that the conventional fluidized bed granulation or wet granulation process easily causes the loss of volatile components or heat-sensitive components in Cordyceps sinensis. If the moisture control is not good in wet granulation, It is prone to technical problems such as sticking, powdering, splitting, falling blocks, and loose tablets. To overcome the above defects, it is usually necessary to add auxiliary materials for shaping, improve the fluidity and water content of granules to ensure the quality of tableting

However, after adding excipients, there will be defects such as uneven mixing and uneven drug content in the tablet

[0005] In a word, there is no report about crushing Cordyceps sinensis into fine powder and then pressing it into tablets without adding any auxiliary materials.

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