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Method of testing oral disintegration tablets of 'Huo Xiang Zheng Qi'

The technology of oral disintegrating tablet and detection method is applied in the detection field of Huoxiang Zhengqi oral disintegrating tablet, and can solve the problems of slow effect, high irritation, poor taste and taste, etc.

Inactive Publication Date: 2009-07-29
ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, although Huoxiangzhengqi water and oral liquid have rapid therapeutic effects, they are highly irritating, have poor taste and mouthfeel, and are not suitable for children and patients who are prone to nausea; Huoxiangzhengqi pills and soft capsules take a long time to dissolve after entering the gastrointestinal tract. , and the effect is slow; at the same time, the production cost of Huoxiangzhengqi Soft Capsules is high, and the drug price is expensive

Method used

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  • Method of testing oral disintegration tablets of 'Huo Xiang Zheng Qi'
  • Method of testing oral disintegration tablets of 'Huo Xiang Zheng Qi'
  • Method of testing oral disintegration tablets of 'Huo Xiang Zheng Qi'

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Experimental program
Comparison scheme
Effect test

Embodiment 2

[0205] Embodiment 2 of the present invention: described quality control method comprises the following contents:

[0206] Properties: The drug is brown to tan tablets; fragrant, pungent, slightly sweet;

[0207] Identification: (1) Take 4 tablets of this preparation, grind finely, add 20ml of n-hexane, sonicate for 15 minutes, filter, evaporate the filtrate to dryness at low temperature, add 2ml of n-hexane to the residue to dissolve, and use it as the test solution; Medicinal material 0.5g, add n-hexane 2ml, sonicate for 15 minutes, filter, and the filtrate is used as the reference medicinal material solution; according to the "Chinese Pharmacopoeia" 2005 edition, an appendix VIB thin-layer chromatography test, absorb 5 μl of each of the above two solutions, and point respectively On the same silica gel G thin-layer plate, develop with 60-90°C petroleum ether: ethyl acetate = 20:1 as the developer, take it out, dry it in the air, and spray with 5% p-dimethylaminobenzaldehyde ...

Embodiment 3

[0219] Embodiment 3 of the present invention: quality control method may comprise the following content:

[0220] Properties: The drug is brown to tan tablets; fragrant, pungent, slightly sweet;

[0221] Identification: (1) Take 4 tablets of this preparation, grind finely, add 20ml of n-hexane, sonicate for 15 minutes, filter, evaporate the filtrate to dryness at low temperature, add 2ml of n-hexane to the residue to dissolve, and use it as the test solution; Medicinal material 0.5g, add n-hexane 2ml, sonicate for 15 minutes, filter, and the filtrate is used as the reference medicinal material solution; according to the "Chinese Pharmacopoeia" 2005 edition, an appendix VIB thin-layer chromatography test, absorb 5 μl of each of the above two solutions, and point respectively On the same silica gel G thin-layer plate, develop with 60-90°C petroleum ether: ethyl acetate = 20:1 as the developer, take it out, dry it in the air, and spray with 5% p-dimethylaminobenzaldehyde in 10% s...

Embodiment 4

[0229] Embodiment 4 of the present invention: quality control method may comprise the following content:

[0230] Properties: The drug is brown to tan tablets; fragrant, pungent, slightly sweet;

[0231] Identification: (1) Take 4 tablets of this preparation, grind finely, add 20ml of n-hexane, sonicate for 15 minutes, filter, evaporate the filtrate to dryness at low temperature, add 2ml of n-hexane to the residue to dissolve, and use it as the test solution; Medicinal material 0.5g, add n-hexane 2ml, sonicate for 15 minutes, filter, and the filtrate is used as the reference medicinal material solution; according to the "Chinese Pharmacopoeia" 2005 edition, an appendix VIB thin-layer chromatography test, absorb 5 μl of each of the above two solutions, and point respectively On the same silica gel G thin-layer plate, develop with 60-90°C petroleum ether: ethyl acetate = 20:1 as the developer, take it out, dry it in the air, and spray with 5% p-dimethylaminobenzaldehyde in 10% s...

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Abstract

The invention provides an oral disintegrating tablet of Huoxiangzhengqi, a preparation method and a quality control method. 24.4g of licorice extract, 1.95ml of patchouli oil, 0.98ml of perilla leaf oil and appropriate auxiliary materials; compared with the prior art, the preparation of the present invention not only has exact curative effect, few adverse reactions, but also can be rapidly absorbed in the oral cavity Disintegration, easy to take, fast absorption, high bioavailability, small irritation to the digestive tract mucosa, and its preparation process is conducive to industrialized large-scale production; modified into oral disintegrating tablets, the drug has a short dissolution time, fast onset, and low cost , suitable for ordinary patients.

Description

Technical field: [0001] The invention relates to a detection method of Huoxiang Zhengqi orally disintegrating tablets, belonging to the technical field of traditional Chinese medicine. Background technique: [0002] Huoxiangzhengqi Powder originated in the Song Dynasty. Its curative effect is outstanding, and it has been honored as the "Holy Medicine for Dispelling Dampness" by physicians of all dynasties. The traditional effect is to relieve the exterior and remove dampness, regulate qi and harmonize the middle. It is mainly used for syndromes of exogenous wind-cold and internal injury and damp stagnation. Huoxiangzhengqi preparations are currently widely used in gastrointestinal colds, acute and chronic enteritis and so on. The dosage form sold on the market has oral liquid, capsule, soft capsule, pill. Among them, although Huoxiangzhengqi water and oral liquid have rapid therapeutic effects, they are highly irritating, have poor taste and mouthfeel, and are not suitable...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61K36/9068A61K9/20A61P1/12A61P31/00G01N30/90G01N33/15
Inventor 陈法贵王天兴徐丽君
Owner ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
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