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Medicinal composition for treating colpitis

A composition and vaginitis technology, applied in the field of medicine, can solve problems such as difficult administration methods, ineffective medicinal ingredients, inability to cure infection, etc., and achieve fast and convenient treatment effects

Inactive Publication Date: 2009-08-12
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many kinds of medicines currently on the market for the treatment of women's vaginitis, the active ingredients of the medicines themselves still cannot achieve a good curative effect, or their functions are mostly limited to disinfection and sterilization, which have the effect of controlling infection, but destroy the microscopic bacteria in the vagina. Ecological balance, so that the infection cannot be cured, or the method of administration is not easily accepted by patients

Method used

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  • Medicinal composition for treating colpitis
  • Medicinal composition for treating colpitis
  • Medicinal composition for treating colpitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1, the preparation of vaginal spray of pharmaceutical composition of the present invention

[0043] prescription:

[0044]

[0045] Preparation Process:

[0046] Take the prescribed amount of cnidium, Polygonum cuspidatum, Sophora flavescens, Baibu, white fresh skin, dry alum, add water and decoct twice, the first time is 2.5 hours, the second time is 1.5 hours, combine the decoction, filter, and the filtrate is concentrated under reduced pressure (0.1Mpa, 60°C) to a relative density of 1.14-1.16, let it cool, add ethanol to make the alcohol content to 70%, refrigerate (below 10°C) and let stand for 24 hours, filter, recover ethanol from the filtrate and concentrate to 500ml. Get the prescribed amount of ketoconazole, add 50ml of 11.7% dilute hydrochloric acid to dissolve, then add glycerin 50g, polysorbate-8050g, HPMC 5g, stir evenly, and merge with the above-mentioned filtrate. Take another prescribed amount of ciprofloxacin and sodium benzoate, dissol...

Embodiment 2

[0047] Embodiment 2, the preparation of pharmaceutical composition suppository of the present invention

[0048] prescription:

[0049]

[0050] Preparation Process:

[0051] Take the prescribed amount of cnidium, Polygonum cuspidatum, Sophora flavescens, Baibu, white fresh skin, dry alum, add water and decoct twice, the first time is 2.5 hours, the second time is 1.5 hours, combine the decoction, filter, and the filtrate is concentrated under reduced pressure (0.1Mpa, 60°C) to a relative density of 1.14-1.16, let it cool, add ethanol to make the alcohol content to 70%, refrigerate (below 10°C) for 24 hours, filter, recover ethanol from the filtrate and concentrate to 1.30-1.35 (25°C) thick paste, set aside. Take another glycerin, heat it to 115°C-120°C, add gelatin (pre-impregnated with appropriate amount of water for 1 hour), stir continuously until the gelatin dissolves, add ciprofloxacin and ketoconazole to the glycerin gelatin matrix, and then add thick paste Afte...

Embodiment 3

[0052] Embodiment 3, the preparation of pharmaceutical composition lotion of the present invention

[0053] prescription:

[0054]

[0055] Preparation Process:

[0056] Take the prescribed amount of cnidium, Polygonum cuspidatum, Sophora flavescens, Baibu, white fresh skin, dry alum, add water and decoct twice, the first time is 2.5 hours, the second time is 1.5 hours, combine the decoction, filter, and the filtrate is concentrated under reduced pressure (0.1Mpa, 60°C) to a relative density of 1.14-1.16, let it cool, add ethanol to make the alcohol content to 70%, refrigerate (below 10°C) and let stand for 24 hours, filter, recover ethanol from the filtrate and concentrate to 500ml. Get the ketoconazole of prescription quantity, add 11.7% dilute hydrochloric acid 50ml to dissolve, then add glycerin 50g, polysorbate-8050g, propylene glycol 50g, stir evenly, merge with above-mentioned filtrate. Take the prescribed amount of ciprofloxacin and sodium benzoate, dissolve the...

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Abstract

The invention discloses a pharmaceutical composition for treating vaginitis, wherein the composition is prepared mainly from cnidium fruit, giant knotweed rhizome, flavescent sophora root, roor of sessile stemona, Chinese dittany bark, dried alum, ciprofloxacin and ketoconazole through steps of grilling herbs with water, concentrating the filtrate, charging ciprofloxacin, ketoconazole and auxiliary materials of predetermined amounts.

Description

1. Technical field [0001] The present invention relates to a kind of pharmaceutical composition and its preparation method mainly made of Cnidium mongolicae, Polygonum cuspidatum, Sophora flavescens, Radix Dictatori, Radix Dicticae, Kulumen, Ciprofloxacin and ketoconazole, as well as the preparation method of the pharmaceutical composition. It is used in the preparation of medicine for treating vaginitis; it belongs to the technical field of medicine. 2. Background technology [0002] Vaginitis is an inflammation of the vaginal mucosa and submucosal connective tissue. It is divided into trichomonal vaginitis, fungal vaginitis, non-specific vaginitis, etc. It is a common gynecological disease. For normal healthy women, due to their anatomical and biochemical characteristics, the vagina has a natural defense function against the invasion of pathogens. When the natural defense function of the vagina is destroyed, pathogens are easy to invade and cause vaginal inflammation. Youn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/904A61K36/75A61K36/704A61K36/489A61K36/234A61K33/06A61K31/496A61K9/02A61K9/08A61K9/12A61P15/02
Inventor 黄振华
Owner SHANDONG XUANZHU PHARMA TECH CO LTD