Bodily fluid markers of tissue hypoxia
A tissue and index technology, applied in the field of body fluid indicators of tissue hypoxia, can solve the problems of tissue hypoxia, insufficient tissue blood perfusion, etc.
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Embodiment 1
[0068] research population
[0069] One hundred and twenty heart failure patients were studied, all with echocardiographically confirmed left ventricular systolic dysfunction (left ventricular (LV) ejection fraction 400IU / L. An echocardiographic study was also performed on 177 of the patients with myocardial infarction, classifying systolic function as normal, mildly dysfunctional, moderately dysfunctional, and severely dysfunctional. Age- and sex-matched normal control subjects with LV ejection fraction >50% were recruited within the local community by advertisement. All subjects submitted informed consent to participate in this study and were approved by the local ethics committee.
[0070] Endpoints in patients with myocardial infarction
[0071] Endpoints were defined as all-cause death and cardiovascular morbidity after discharge from standard hospital care (rehospitalization due to heart failure). Multivariate analyzes were performed for all endpoints except death aft...
Embodiment 2
[0129] An additional 114 patients with unstable angina or non-ST-elevating myocardial infarction (subendocardial myocardial infarction, defined as creatinine kinase levels elevated below 2 times the upper limit of normal) were studied. All patients had chest pain at rest and were admitted to hospital. Mean (range) age was 66.8 years (38-93), 74 males and 40 females. Blood samples were collected 3-5 days after admission, and the levels of troponin T (Roche Diagnostics), ORP150 protein and N-BNP were analyzed using the method described in Example 1.
[0130] Patients were followed for myocardial infarction patient endpoints as described in Example 1.
[0131] Nine deaths occurred during a mean follow-up period of 401 days (range 26-764 days). Troponin T levels were not significantly different in patients who died (0.12 (0.005-1.14) μg / L) compared to those in surviving patients (0.19 (0.005-0.557) μg / L).
[0132] In contrast, ORP150 and N-BNP levels were significantly elevated...
Embodiment 3
[0141] The impact of acute obstruction during balloon angioplasty on coronary circulation was evaluated in 19 patients with coronary artery disease who were undergoing balloon angioplasty for atherosclerosis. Plasma was collected before and 2, 6 and 12 hours after angioplasty. ORP150 levels were measured as described above. In addition, using immunoluminescence photometry in C 18 On-column measurements of levels of a cardiac marker known to indicate ventricular wall stress, type B or brain natriuretic peptide (BNP), are known to increase after other coronary occlusive events such as myocardial infarction will rise.
[0142] Figure 17 Changes in ORP150 levels in plasma after angioplasty are shown and compared to changes in BNP levels. Both indicators had significant changes over time (multiple measures ANOVA P<0.001). Furthermore, both peptide levels peaked 2 hours after angioplasty and decreased back to baseline thereafter. The peak of ORP150 level at 2 hours was signif...
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