Medicine combination of tuber of dwarf lilyturf and asarone

A composition and technology of Asarum, applied in the field of medicine, achieves the effects of wide application prospect, simple preparation process and guaranteed safety

Inactive Publication Date: 2009-10-14
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, using the interaction of Radix Ophiopogon japonicus or its extracts and asarum, compatible prescriptions, for the preparation of medicines for the treatment of pneumonia, bronchial asthma, chronic obstructive pulmonary disease with cough, expectoration, wheezing and other diseases, has not been reported

Method used

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  • Medicine combination of tuber of dwarf lilyturf and asarone
  • Medicine combination of tuber of dwarf lilyturf and asarone
  • Medicine combination of tuber of dwarf lilyturf and asarone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] The preparation of embodiment 1 Ophiopogon japonicus polysaccharide

[0131] Take the dried Ophiopogon japonicus root, extract with ethanol reflux three times, discard the ethanol extract, evaporate the solvent from the dregs, add water to decoct three times, add 6 times the amount of water each time, and the extraction time is 2 hours, 1 hour, and 1 hour respectively. Combine the water extracts, filter, add 0.5% activated carbon for decolorization twice, filter with suction, concentrate the filtrate under reduced pressure to 1 / 5 of the original volume, put it in the refrigerator for more than 24 hours, centrifuge, filter, add ethanol to the filtrate until the alcohol content is 80%, put it in the refrigerator to stand overnight, filter, wash the filter residue several times with absolute ethanol, evaporate the ethanol, add water to heat to dissolve, stand overnight, and centrifuge to remove the precipitate. Adjust the pH of the supernatant to 2.5-5, add 1% pepsin or ...

Embodiment 2

[0144] The preparation of embodiment 2MX composition powder injection

[0145] 1. Prescription:

[0146] Prescription 1:

[0147] Ophiopogon japonicus polysaccharide 125g (equivalent to Ophiopogon japonicus 10kg)

[0148] Asarum 16g

[0149] Polysorbate 80 45g

[0150] Mannitol 500g

[0151] Sorbitol 50g

[0152] Add sterile water for injection to 5000ml

[0153]

[0154] A total of 1000 sticks were prepared

[0155] Prescription 2:

[0156] Ophiopogon japonicus polysaccharide 75g (equivalent to Ophiopogon japonicus 6kg)

[0157] Asarum 90g

[0158] Polysorbate 80 50g

[0159] Mannitol 500g

[0160] Sorbitol 50g

[0161] Add sterile water for injection to 5000ml

[0162]

[0163] A total of 1000 sticks were prepared

[0164] Prescription 3:

[0165] Ophiopogon japonicus polysaccharide 200g (equivalent to Ophiopogon japonicus 16kg)

[0166] Asarum 10g

[0167] Polysorbate 80 100g

[0168] Manni...

Embodiment 3

[0184] The preparation of embodiment 3 composition aqueous injections

[0185] 1. Prescription:

[0186] Prescription 1:

[0187] Ophiopogon japonicus polysaccharide 125g (equivalent to Ophiopogon japonicus 10kg)

[0188] Asarum 16g

[0189] Ethanol 200ml

[0190] Add water for injection to 5000ml

[0191]

[0192] A total of 1000 sticks were prepared

[0193] Prescription 2:

[0194] Ophiopogon japonicus polysaccharide 100g (equivalent to Ophiopogon japonicus 8kg)

[0195] Asarum 24g

[0196] Ethanol 200ml

[0197] Add water for injection to 5000ml

[0198]

[0199] A total of 1000 sticks were prepared

[0200] Prescription 3:

[0201] Ophiopogon japonicus polysaccharide 150g (equivalent to Ophiopogon japonicus 12kg)

[0202] Asarum 12g

[0203] Ethanol 200ml

[0204] Add water for injection to 5000ml

[0205]

[0206] A total of 1000 sticks were prepared

[0207] 2. Speci...

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PUM

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Abstract

The invention belongs to the technical field of medicine, and discloses a new pharmaceutical composition for treating respiratory diseases and its preparation method and application. 1 to 300 parts of asarone and pharmaceutically acceptable auxiliary materials are made into various pharmaceutically acceptable dosage forms, preferably injection or oral preparation; for the treatment of pneumonia, bronchial asthma, chronic obstructive pulmonary disease with cough, expectoration, It has a good curative effect on diseases such as wheezing, produces unexpected effects, and has a wide application prospect.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition mainly made of Ophiopogon japonicus or its extract and asarone, its preparation method and application, belonging to the technical field of medicine. 2. Background technology [0002] Respiratory system diseases mainly include upper respiratory tract infection, acute and chronic bronchitis, pneumonia and other diseases. They are one of the diseases that people are familiar with. , wheezing, and inflammation are its common characteristics, while inflammation is the cause of the disease, and cough, phlegm, and wheezing are secondary symptoms. These symptoms will affect the patient's rest and health. If they do not heal for a long time, they may develop into emphysema, bronchiectasis, and cor pulmonale. Respiratory diseases mostly occur in winter and spring, mostly caused by virus infection first, and a few caused by direct bacterial infection. The theory of traditional Chinese medicine believes t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K31/09A61P11/00
Inventor 黄振华
Owner JIANGYIN TIANJIANG PHARMA
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