Hard medicine capsule

[0011] Example 1.

[0012] The active ingredients of the hard drug capsules of the present invention are composed of: 35% by weight of hydroxypropyl methylcellulose; 55% of hydroxypropyl starch; 10% of chitin; and the technological process of making the capsule is: preparing an aqueous solution. The concentration of the aqueous solution is 10%; the viscosity of the aqueous solution is 1000 centipoise; the aqueous solution is allowed to stand or depressurize to completely degas in the gel tank, preheat the shaft needle to 70℃ before immersing the liquid, then immerse it in the aqueous solution with a heating temperature of 40℃, and place it for 2 Minutes; take out the shaft needle and dry it in a closed drying box at a drying temperature of 30°C; form a hard shell-like polymer blend film on the shaft needle, pull out the shaft needle after demolding, and make it after trimming Hard drug capsule shell;

[0013] The capsule sleeve adopts a shaft needle with a diameter larger than the capsule shell to prepare an aqueous solution through the above-mentioned technological process, soak in liquid, dry, demould, and trim to obtain the capsule sleeve, which is sleeved with the capsule shell to obtain a plant capsule.

[0014] The said capsules are mainly blends. The raw materials of the effective ingredients of the capsules can also be mixed with known additives, such as plasticizers: glycerin, sorbitol, mannitol, sucrose, polyethylene glycol, etc. , Such as sunscreen: titanium dioxide, barium sulfate, precipitated calcium carbonate, etc., such as colorants: water-soluble pigments, lake pigments, etc. Gelling agent: sodium alginate, carrageenan, pectin, ethylene copolymer, alginic acid, etc. account for 0.1-3% of the total content of the above-mentioned main ingredients, and surfactants account for 0.001-0.02% of the total content of the above-mentioned main ingredients.

[0015] The test failure time is 6.5 minutes.

[0016] Example 2.

[0017] The active ingredients of the hard drug capsules of the present invention are composed of 40% by weight of hydroxypropyl methylcellulose; 47% of hydroxypropyl starch; 13% of chitin; and the technological process of making the capsule is: preparing an aqueous solution. The concentration of the aqueous solution is 20%; the viscosity of the aqueous solution is 5000 centipoise; the aqueous solution is allowed to stand or depressurize to completely degas in the gel tank, preheat the shaft needle to 75℃ before immersing the liquid, then immerse it in the aqueous solution with heating temperature of 50℃, and place 2 Minutes; take out the shaft needle and dry it in a closed drying box at a drying temperature of 35°C; form a hard shell-like polymer blend film on the shaft needle, pull out the shaft needle after demolding, and make it after trimming Hard drug capsule shell;

[0018] The capsule sleeve adopts a shaft needle with a diameter larger than the capsule shell to prepare an aqueous solution through the above-mentioned technological process, soak in liquid, dry, demould, and trim to obtain the capsule sleeve, which is sleeved with the capsule shell to obtain a plant capsule.

[0019] The said capsules are made of blends as the main ingredient. The raw materials of the effective ingredients can also be mixed with known additives, such as glycerol, sorbitol, mannitol, sucrose, polyethylene glycol and other plasticizers. Such as titanium dioxide, barium sulfate, precipitated calcium carbonate and other sunscreen agents, such as water-soluble pigments, lake pigments and other colorants. Gelling agent: sodium alginate, carrageenan, pectin, ethylene copolymer, alginic acid, etc. account for 0.1-3% of the total content of the above-mentioned main ingredients, and surfactants account for 0.001-0.02% of the total content of the above-mentioned main ingredients.

[0020] After the test, the destruction time was 6.8 minutes.

[0021] Example 3.

[0022] The active ingredients of the hard drug capsules of the present invention are composed of: 45% by weight of hydroxypropyl methylcellulose; 40% of hydroxypropyl starch; 15% of chitin; and the technological process of capsule manufacturing is: preparing an aqueous solution. The concentration of the aqueous solution is 30%; the viscosity of the aqueous solution is 10000 centipoise; the aqueous solution is allowed to stand or depressurize to completely degas in the glue tank, and the shaft needle is preheated to 80℃ before immersing the liquid, then immersed in the aqueous solution with a heating temperature of 60℃, and placed 2 Minutes; Take out the shaft needle and dry it in a closed drying box at a drying temperature of 55°C; form a hard shell-like polymer blend film on the shaft needle, pull out the shaft needle after demolding, and make it after trimming Hard drug capsule shell;

[0023] The capsule sleeve adopts a shaft needle with a diameter larger than the capsule shell to prepare an aqueous solution through the above-mentioned technological process, soak in liquid, dry, demould, and trim to obtain the capsule sleeve, which is sleeved with the capsule shell to obtain a plant capsule.

[0024] The said capsules are made of blends as the main ingredient. The raw materials of the effective ingredients can also be mixed with known additives, such as glycerol, sorbitol, mannitol, sucrose, polyethylene glycol and other plasticizers. Such as titanium dioxide, barium sulfate, precipitated calcium carbonate and other sunscreen agents, such as water-soluble pigments, lake pigments and other colorants. Gelling agent: sodium alginate, carrageenan, pectin, ethylene copolymer, alginic acid, etc. account for 0.1-3% of the total content of the above-mentioned main ingredients, and surfactants account for 0.001-0.02% of the total content of the above-mentioned main ingredients.

[0025] The test failure time was 7.3 minutes.