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Method for extracting dihydromyricetin from Japanese raisin tree seed

A technology of dihydromyricetin and Fructus Aurantii, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of high toxicity and cumbersome extraction process, achieve low toxicity and overcome cumbersome operation processes , controllable effect

Inactive Publication Date: 2007-08-01
GUANGDONG PHARMA UNIV
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the main plant source of dihydromyricetin today is the vine tea of ​​the genus Vitis genus, and its extraction process is cumbersome and highly toxic

Method used

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  • Method for extracting dihydromyricetin from Japanese raisin tree seed
  • Method for extracting dihydromyricetin from Japanese raisin tree seed
  • Method for extracting dihydromyricetin from Japanese raisin tree seed

Examples

Experimental program
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Embodiment 1

[0022] 1. Get the dry seeds (1kg) of Hovenia dulcis, remove impurities, pulverize them, and pass through a 80-100 mesh sieve;

[0023] 2. Use 8 times the amount of petroleum ether with a boiling range of 60-90 to reflux extraction for 2 hours, and then use 6 times the amount of petroleum ether with a boiling range of 60-90 to reflux extract twice, each time for 1.5 hours, filter to obtain a filter residue , combine the extracts, and recover the solvent.

[0024] 3. The filter residue obtained above was reflux extracted with 8 times the amount of 70% ethanol for 2 hours, and then refluxed with 70% ethanol for 2 times, each time for 1.5 hours;

[0025] 4. Concentrate the extract under reduced pressure, put it on the AB-8 macroporous resin column, load the sample slowly, first elute with water until the effluent is nearly colorless, then use 10% ethanol to elute for 5 times the column retention volume, and finally use 30% Ethanol elution, when the elution reaches 6 times the col...

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Abstract

The invention discloses a method for extrating dihydromyricetin from Hovenia Dulcis Thunb. The method comprises following steps: pretreating medicinal materials and getting extracting liquid of dihydromyricetin, purifying with resin, recrystallizing and getting high- purity dihydromyricetin (the purity is over 99%). The invention is characterized by easy operation, less toxicity, low cost, convenient control and feasibility for large- scale production.

Description

technical field [0001] The invention relates to dihydromyricetin, in particular to a method for extracting dihydromyricetin from Hovenia dulcis fruit. Background technique [0002] Hovenia dulcis Thunb., Hovenia acerba Lindl. and Hovenia trichocarpa Chun et al. Tsiang) has a medicinal history of thousands of years. There are 3 species and 2 varieties in the world, mainly distributed in China, Korea, Japan and India. Our country is very rich in resources, which are distributed in all provinces except Northeast my country, Inner Mongolia, Xinjiang, Ningxia, Qinghai and Taiwan. It was first recorded in "Tang Materia Medica", and it is used as medicine with fruits, seeds, wood juice, and wood bark. It is now recorded in "Drug Standards of the Ministry of Health of the People's Republic of China Chinese Medicinal Materials". Flavonoids are the active ingredients of Hovenia dulcis. According to the pharmacological experiment reports of Japanese scholars, it has been confirmed th...

Claims

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Application Information

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IPC IPC(8): C07D311/32A61K36/72A61K131/00
Inventor 张德志申向荣
Owner GUANGDONG PHARMA UNIV
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