Preparation and structure of novel para-insulin pharmaceutical model compound

A complex and a suitable technology, which can be used in the fields of compounds containing elements of group 5/15 of the periodic table, compounds containing elements of group 3/13 of the periodic table, organic chemistry, etc., and can solve problems such as difficult absorption and toxicity

A complex and a suitable technology, which can be used in the fields of compounds containing elements of group 5/15 of the periodic table, compounds containing elements of group 3/13 of the periodic table, organic chemistry, etc., and can solve problems such as difficult absorption and toxicity

CN101033239AInactive Publication Date: 2007-09-12LIAONING NORMAL UNIVERSITY
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  • Preparation and structure of novel para-insulin pharmaceutical model compound
  • Preparation and structure of novel para-insulin pharmaceutical model compound
  • Preparation and structure of novel para-insulin pharmaceutical model compound

Examples

Experimental program
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example 1

[0014] 0.238g (1mmol) NaHB (pz) 3 Dissolved in 5ml methanol; 0.199g, (1mmol) VOSO 4 ·nH 2 O and 0.164 g (1 mmol) of ammonium pyrrolidine dithiocarbamate were dissolved in 5 ml of methanol. The above two solutions were mixed and stirred for 6 hours to obtain a yellow-green solution, and gradually a yellow-green precipitate appeared. Then, it was filtered, and the precipitate was washed with methanol and dried in air to give a blue solid and a yellow-green solution. Solid compound weighs 0.30g, and productive rate is 70%, and solid compound is in CH 2 Cl 2 / MeOH (5:2) to obtain blue crystals suitable for X-ray diffraction analysis after a few days. Elemental analysis: theoretical value, C 39.42, H 4.22, N 22.99%; measured value, C 39.25, H 4.55, N 22.46%.

example 2

[0016] 0.238g (1mmol) NaHB (pz) 3 Dissolved in 5ml ethanol; 0.199g, (1mmol) VOSO 4 ·nH 2 O and 0.164 g (1 mmol) of ammonium pyrrolidine dithiocarbamate were dissolved in 5 ml of ethanol. The above two solutions were mixed and stirred for 6 hours to obtain a yellow-green solution, and gradually a yellow-green precipitate appeared. Then, it was filtered, and the precipitate was washed with ethanol and dried in air to obtain a blue solid and a yellow-green solution. Solid compound weighs 0.28g, and productive rate is 65%, and solid compound is in CH 2 Cl 2 / EtOH (5:2) to obtain blue crystals suitable for X-ray diffraction analysis after a few days. Elemental analysis: theoretical value, C 39.42, H 4.22, N 22.99%; measured value, C 39.25, H 4.55, N 22.46%.

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Abstract

Vanadium can promote glucose transport, metabolism, synthesis of biological fat, protein and DNA, and cell division. In addition, it has the functions of stimulating glucose absorption, sugar solution and anti-tumor. But VO2+ is toxic and difficult to absorb, so the invention chooses an appropriate substituent poly pyrazole borate as ligand to combine with VD forming quadrivalence or quinquevalence organic compound to reduce toxicity.

Description

technical field [0001] This patent involves the preparation and structural characterization of a new insulin-like drug model compound. The synthesis method of the compound is simple, the conditions are easy to control, and the raw materials are easy to obtain. technical background [0002] At present, people pay more and more attention to the research on the design and synthesis of drug molecules for treating diabetes, especially the development and research of insulin-like drugs. Among them, the research on vanadium compounds with insulin-like activity has attracted much attention. Because, although the content of vanadium in plants and animals is very small, its compounds have very interesting biological and pharmaceutical activities, especially insulin-like activities. Vanadium can promote blood sugar transportation and metabolism, biolipid, DNA and protein synthesis, and also promote cell division. In addition, vanadate also has the functions of stimulating blood suga...

Claims

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Application Information

Patent Timeline
12 Sep 2007
Publication
CN101033239A
IPC
C07F19/00; C07F9/00; C07F5/02
Inventors
邢永恒; 白凤英