Compositions and methods for treating ophthalmic diseases

An eye disease, compound technology, applied in metabolic diseases, drug combinations, sensory diseases, etc., can solve problems such as damage to the peripheral retina, visual loss, etc.
CN101035537AInactive Publication Date: 2007-09-12MERCK & CO INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MERCK & CO INC
Publication Date
2007-09-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to CXCR4 inhibitors and their use in treating and / or preventing a variety of angiogenic, microvascular and ocular disorders including primary indications for diabetic retinopathy, macular degeneration (such as wet or neovascular age-related macular degeneration (AMD) and dry or atrophic AMD), macular edema, and secondary indications for inhibiting tumor vascularization, and corneal and iris neovascularization.
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Description

Background of the invention

[0001] Inappropriate growth of blood vessels in adults contributes to a variety of pathogenic conditions. For example, supporting tumor growth by providing oxygen and nutrients through the formation of new blood vessels. In the eye, growth of the normally resting vasculature can lead to retinal damage, visual impairment or blindness. Neovascular (or wet) AMD and diabetic retinopathy are the most prevalent diseases of the ocular vasculature and are the leading causes of blindness in populations in developed countries. The current standard of care for ocular neovascular disease is laser surgery (photocoagulation or photodynamic therapy). Unfortunately laser surgery is moderately effective and only available in a small fraction of the AMD patient population. For DR, laser therapy is effective in reducing blood vessel growth in many patients, however, laser therapy destroys portions of the peripheral retina, which itself can lead to vision loss. The...

Claims

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