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Methods and devices for renal nerve blocking

A nerve block, renal nerve technology, used in the field of treatment of diseases, can solve problems such as systemic infection, pain, and patient health risks

Active Publication Date: 2007-09-12
MEDTRONIC ARDIAN LUXEMBOURG SARL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is possible, but not practical, because refilling the pump is associated with skin punctures, which can cause pain and risk of local as well as systemic infection
At the same time, the daily infusion of large amounts of drugs can pose serious risks to the patient's health, especially if the patient's heart is weak

Method used

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  • Methods and devices for renal nerve blocking
  • Methods and devices for renal nerve blocking
  • Methods and devices for renal nerve blocking

Examples

Experimental program
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Embodiment Construction

[0037] For the proposed clinical use, the ability of the present invention is to block renal renal sympathetic activity through controlled local delivery of neuroleptics with the goal of improving renal and cardiac function in patients. For uses other than treating cardiorenal disease, elements of the invention are also useful for blocking nerves and may be applied to other anatomical locations.

[0038] A neuroleptic is a drug that reduces or blocks the signaling in the kidney nerves. Nerve blocking agents used can be selected from different groups, including (1) local anesthetics, (2) ketamine (a well-known sedative, which has nerve blocking properties), (3) tricyclic antidepressants, such as amida Tripline, (4) neurotoxins such as tetrodotoxin and saxitoxin, or (5) any other class or type of agent that temporarily or permanently, partially or completely alters nerve conduction. The terms nerve blocking agent and nerve blocking drug are interchangeable.

[0039] Cardiorena...

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Abstract

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and / or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for extravascular delivery of pulsed electric fields to achieve such neuromodulation.

Description

technical field [0001] The present invention relates to devices and methods for localized drug delivery, and is particularly directed to an implantable system, a method of implanting the implantable system, and a method and device for treating disease, wherein the implantable system is used to prevent Targeted delivery of neuroleptics to the periarterial space of the renal arteries by blocking the renal plexus. The present invention directs the nerve-blocking agent to the nerve, prevents the nerve-blocking agent from dissipating in the surrounding tissue, and provides immobilization of the drug delivery system in the surrounding tissue. [0002] related application [0003] The current application relates to, and claims the benefit of, the following co-owned application: Serial No. 60 / 408,665, filed April 8, 2003 in the United States Patent and Trademark Office (USPTO), entitled "Renal Nerve Stimulation Method and Apparatus for Treating a Patient" , and, Provisional Applicat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/40
CPCA61M2210/1082A61M5/14276A61M5/1723A61M2005/1726A61N1/36017A61B5/4041A61B5/201A61B5/6852
Inventor 马克·盖尔芬德霍华德·R·勒万
Owner MEDTRONIC ARDIAN LUXEMBOURG SARL
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