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Oral preparation for treating chough and its preparing process

A technology of oral preparations and excipients, which is applied in the field of oral preparations for cough treatment and its preparation, which can solve the problems of complex prescriptions, strong water absorption, and poor drug stability of cough medicines, and achieve rich and flexible choices, cost savings, and increased stability. Effect

Active Publication Date: 2007-09-19
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the preparation of the Keke preparation is recorded in the ministerial standards, the prescription of the Keke preparation is complicated, and the drug has a high ointment rate, strong water absorption, and relatively complicated contents, so the stability of the drug is relatively poor, and the addition of excipients It can enhance the stability of the drug to a large extent. If the excipients are not properly selected, it is easy to cause the drug material to fail to meet the standards in terms of fluidity, appearance, moisture content and disintegration time limit.
The specific types and dosage of excipients in the product are not recorded in the ministerial standards. During the product research, the applicant found that improper selection of excipients is the main reason for the poor stability of the cough preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1: Ephedra 180.5g, poppy shell 180.5g, licorice 180.5g, bitter almond 180.5g, radish seed 56.4g, bellflower 56.4g, gypsum 56.4g.

[0066] Preparation process: prepare capsules of the present invention according to the following steps:

[0067] a. Take ephedra and poppy shells and crush them into fine powder, sieve, and leave 83g of fine powder for subsequent use. The fine powder is product A, and the remaining coarse powder is product B;

[0068] b. Decoct product B with an acidic aqueous solution with a pH value of 5 (the acidic aqueous solution is adjusted to a pH value of 5 with 10% hydrochloric acid solution) decocting twice, each time for 2 hours, filter, combine the filtrate, and oxidize the filtrate with 10% hydroxide Adjust the pH value of the sodium solution to 7 to obtain product C;

[0069] c. Take licorice, bitter almonds, radish seeds, platycodon grandiflorum, and gypsum, add water and decoct twice, each time for 1 hour, filter, and combine the fil...

Embodiment 2

[0072] Example 2: 126g of ephedra, 126g of poppy shell, 126g of licorice, 126g of bitter almond, 40g of radish seed, 40g of bellflower, and 40g of gypsum.

[0073] Preparation process: prepare capsules of the present invention according to the following steps:

[0074] a. Take ephedra and poppy shells and grind them into fine powder, sieve, and leave 66g of fine powder for subsequent use. The fine powder is product A, and the remaining coarse powder is product B;

[0075] b. Decoct product B with an acidic aqueous solution with a pH value of 3 (an acidic aqueous solution is to adjust the pH value to 3 with 20% hydrochloric acid solution) for 5 hours, filter, and combine the filtrates, and adjust the pH value of the filtrate with 2% sodium hydroxide solution To 6, get product C;

[0076] c. Take licorice, bitter almonds, radish seeds, platycodon grandiflorum, and gypsum, add water and decoct for 5 hours, filter, and combine the filtrates to obtain product D;

[0077] d. Combi...

Embodiment 3

[0079] Example 3: 234g of ephedra, 234g of poppy shell, 234g of licorice, 234g of bitter almond, 80g of radish seed, 80g of bellflower, and 80g of gypsum.

[0080] Preparation process: prepare capsules of the present invention according to the following steps:

[0081] a. Take ephedra and poppy shells and crush them into fine powder, sieve, and leave 116g of fine powder for later use. The fine powder is product A, and the remaining coarse powder is product B;

[0082] b. Decoct product B with an acidic aqueous solution with a pH value of 6 (the acidic aqueous solution is adjusted to a pH value of 6 with 2% hydrochloric acid solution) decocting 5 times, each time for 0.5 hours, filter, combine the filtrates, and oxidize the filtrate with 20% hydroxide Adjust the pH value of the sodium solution to 8 to obtain product C;

[0083] c. Take licorice, bitter almonds, radish seeds, platycodon grandiflorum, and gypsum, add water and decoct 5 times, each time for 0.5 hours, filter, and...

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PUM

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Abstract

The invention discloses an oral preparation for treating cough and a preparing method thereof, which belongs to medicine technology art. The oral preparation is formed by ephedra herb, poppy shell, glycyrrhiza uralensis, bitter almond, radish seed, ballonflower, gypsum and proper accessory. The key point of the invention is how to select the proper accessory, and how to form a drug having a fine reliable and good curative effect, together with the raw materials. In the invention, by a series of tests, either microcrystalline cellulose or calcium carbonate is selected as an accessory so that flexibility for selecting accessory in the production process is improved. The preparation for treating cough added with the accessory is up to the standard in fluidity of the drug, appearance, moisture, disintegration, etc of the product, thereby, defect in existing technology is conquered, the reliability of the drug is increased.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an oral preparation for treating cough and a preparation method thereof. Background technique [0002] Cough is a common disease in our daily life. The anti-cough preparation is developed on the basis of Maxing Shigan Decoction in "Treatise on Febrile Diseases". It is composed of seven medicines including seedlings, bellflowers, and gypsum; it has the effects of clearing lung heat, relieving cough, and relieving asthma, and has definite curative effects on upper respiratory tract infection, bronchitis, pneumonia, cough and other diseases. Although the preparation of the Keke preparation is recorded in the ministerial standards, the prescription of the Keke preparation is complicated, and the drug has a high ointment rate, strong water absorption, and relatively complicated contents, so the stability of the drug is relatively poor, and the addition of excipients It ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/48A61P11/14A61K33/06
Inventor 叶湘武汤琼李芙蓉
Owner GUIZHOU YIBAI PHARMA CO LTD