Stable antibiotic powder injection

Abstract

A stable powder injection of antibiotic is proportionally prepared from aseptic mezlocillin and aseptic cosolvent chosen from sodium carbonate, arginine, sodium bicarbonate and sodium hydroxide through mixing.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a stable antibiotic powder injection. Background technique [0002] Mezlocillin (Mezlocillin) belongs to the benzimidazole penicillin, the chemical name is 2S, 5R, 6R)-3,3-dimethyl-6{(R)-2{(3-(methylsulfonyl)-2-oxo Generation-1-imidazolidinecarbonamide}-2-phenylacetamide}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, the structural formula is as follows: [0003] [0004] As the third-generation semi-synthetic penicillin, mezlocillin has a broad antibacterial spectrum. It has antibacterial effects on most Gram-negative bacteria (including Pseudomonas aeruginosa), Gram-positive bacteria and various anaerobic bacteria. Lactamase has a certain stability. Its clinical curative effect is positive, and it is mainly used to treat infection of kidney, urethra, respiratory tract, biliary tract, genitals, soft tissue, abdomen and other parts or organs, as well as sepsis, wi...

AI Technical Summary

Problems solved by technology

The high content of impurities is likely to cause high adverse reactions in clinical use. At present, patients with mezlocillin sodium for injection have experienced dizziness, tinnitus, allergic reactions, anaphylactic shock, external genital edema and other adverse reactions, especially allergic reactions. Reactions and anaphylactic shock are basically caused by impurities [see the literature "Pharmaceutical Herald" 2001(5), 330]

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