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Method for preparing extractive of Chinese traditional medicine rich in coniferyl alcohol ferulic acid, and application in preparing medication, health products, or cosmetic

A technology of coniferyl ferulic acid and extract, which is applied in the field of preparation of Chinese medicine extracts, and can solve the problems of inconvenient industrial production and complex separation and purification methods of coniferyl ferulic acid

Inactive Publication Date: 2007-10-10
李绍平
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing separation and purification methods of coniferyl ferulate are complicated and not convenient for industrial production
In addition, Angelica sinensis has antioxidant and anti-platelet aggregation effects [Huang Guixiang. Shizhen Guoyi Guoyao 2001, 12: 262-263.; Wang Fang, Li Dong. Chinese Pharmacy 2003, 14: 630-631.], but ferulic acid Whether coniferyl ester has such effects has not been reported

Method used

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  • Method for preparing extractive of Chinese traditional medicine rich in coniferyl alcohol ferulic acid, and application in preparing medication, health products, or cosmetic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Chinese medicine angelica powder is extracted by carbon dioxide supercritical extraction (extraction pressure 25MPa, extraction temperature 40°C, extraction time 4h) or organic solvent (10 times the amount of traditional Chinese medicine), and then the organic solvent is evaporated to prepare essential oil.

[0038] Take 50g of the above-mentioned angelica oil, add 500ml n-octane (or n-hexane, or cyclohexane, or methylcyclohexane, or n-heptane), ultrasonically extract for 10min, pour out the supernatant, and add 500ml n-octane to the residue. octane, repeat the above extraction process for a total of 5 times, and dry the residue to obtain coniferyl ferulate concentrate.

[0039] The coniferyl ferulic acid enrichment is detected by HPLC, calculated according to the normalization method, at 318nm (coniferyl ferulic acid maximum absorption wavelength), the peak area percentage of coniferyl ferulic acid is 79.9% (40.5%~79.9%) ), the extraction rate was 79.3% (49.5%-87.6%). ...

Embodiment 2

[0041] Get the angelica oil 30g of carbon dioxide supercritical extraction, add 100ml n-hexane (or cyclohexane, or methylcyclohexane, or n-heptane, or n-octane), 100ml 95% ethanol (or methyl alcohol, or propanol, Or isopropanol, or n-butanol), 50ml water, static layering. After separation, 100 ml of n-hexane was added to the lower water-alcohol phase, and the above extraction operation was repeated for a total of 3 times. The final obtained water-alcoholic phase is recycled to dryness to obtain the coniferyl ferulate enriched product.

[0042] The coniferyl ferulic acid enrichment is detected by HPLC, calculated according to the normalization method, at 318nm, the coniferyl ferulic acid peak area percentage is 62.0% (62.0%-62.6%), and the extraction rate is 28.5% (28.5%) -63.4%). The enrichment of coniferyl ferulate has obvious anti-oxidation and anti-platelet aggregation effects.

Embodiment 3

[0044] Mix n-hexane, ethyl acetate, ethanol and water at a ratio of 1:1:1:1, let stand to separate layers, take the upper layer (organic layer) as the stationary phase, and the lower layer (alcoholic water) as the mobile phase, and carry out countercurrent chromatography. In the washing method, the stationary phase is injected into the high-efficiency countercurrent chromatograph at a flow rate of 5ml / min and 300rpm (the rotor is 240ml). After the rotor is filled with the stationary phase, the mobile phase is injected into the high-performance countercurrent chromatograph at a flow rate of 2ml / min and 1500rpm. Injection. Sampling method: Dissolve 1.5g angelica oil in 4ml mixed solvent (2ml mobile phase + 2ml stationary phase) and inject the sample, collect the chromatographic peak of coniferyl ferulate, detect by HPLC, calculate according to the normalization method, at 318nm , the peak area percentage of coniferyl ferulate was >93%, and the extraction rate was 71.2%. The enr...

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Abstract

A process for preparing the Chinese-medicinal extract rich in coniferylester ferulate includes such steps as providing the powder of Chinese-medicinal material rich in coniferylester ferulate, supercritical CO2 extracting or organic solvent extracting, volatilizing the organic solvent to obtain refined oil, extracting by the mixture of organic solvents or organic solvent, and evaporating out the organic solvent. The application of said extract in preparing medicine, health-care product, or cosmetics for preventing and treating cardiovascular and cerebrovascular diseases is also disclosed.

Description

technical field [0001] The present invention belongs to the preparation and application of active components of traditional Chinese medicine, in particular to a method for preparing a Chinese medicine extract rich in coniferyl ferulate, and the Chinese medicine extract rich in coniferyl ferulate in the preparation of anti-aging and Application in drugs, health products or cosmetics for preventing and treating cardiovascular and cerebrovascular diseases. Background technique [0002] Cells can produce many free radicals in the process of metabolism, excessive free radicals can cause tissue damage, and then cause a variety of diseases, such as aging and heart, brain, blood and brain diseases [Huang Jin, Yang Guoyu, Li Hongji, etc. Nature Magazine 2004 , 26, 74-78; Ling Guanting. Grain and Oil 2003, 9, 50-53; Valko M, Leibfritz D, Moncol J, et al.Int.J.Biochem.Cell Biol.2007, 39, 44-84.] . Synthetic antioxidants such as BHT and BHA have potential toxic and side effects on org...

Claims

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Application Information

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IPC IPC(8): A61K36/232A61K36/236A61K8/97A61K31/222A61P39/06A61P9/00A61P7/02A61K125/00
Inventor 李绍平于玥李苏颖张庆文
Owner 李绍平
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