Method of detecting platelet thrombosis or organ injury

A vascular and vascular technology, applied in the field of disseminated intravascular coagulation, can solve the problems of self-tissue damage, low specificity, tissue damage, etc., and achieve the effects of rapid detection, high specificity detection, and high clinical value.
CN101056989AInactive Publication Date: 2007-10-17MITSUBISHI KAGAKA IATRON INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MITSUBISHI KAGAKA IATRON INC
Publication Date
2007-10-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a method of detecting platelet thrombosis or organ injury in a patient suffering from disseminated intravascular coagulation (DIC) syndrome or systemic inflammatory response syndrome (SIRS) by analyzing a von Willebrand factor-degrading enzyme and / or a degrading factor thereof. A kit for detecting platelet thrombosis or organ injury in a patient suffering from DIC or SIRS which contains an antibody capable of binding specifically to a von Willebrand factor-degrading enzyme or its fragment and an antibody capable of binding specifically to a degrading factor of a von Willebrand factor-degrading enzyme or its fragment.
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Description

technical field

[0001] The present invention relates to a detection method of platelet thrombus or organ damage, especially the detection method for patients with disseminated intravascular coagulation (Disseminated Intravascular Coagulation; DIC) or systemic inflammatory response syndrome (Systemic inflammatory response syndrome; SIRS). According to the present invention, platelets can be detected by analyzing von Willebrand factor (vWF) and / or its decomposition factor in a biological sample (for example, blood) of a subject (in particular, a DIC or SIRS patient) Thrombosis or organ damage, for example, detecting or predicting the degree of platelet thrombus formation, predicting the incidence of thrombosis or organ damage (that is, risk assessment of the onset), judging the presence or absence of thrombosis or organ damage, Prediction, monitoring, and determination of treatment methods for the prognosis of thrombosis or organ damage. Background technique

[0002] DIC is s...

Claims

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