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Application of wogonin in the preparing of medicine for treating gastric cancer

A wogonin and treatment technology, applied in the field of pharmacy, can solve problems such as no literature report on the application of wogonin, and achieve the effect of being beneficial to clinical application and having little toxic effect

Active Publication Date: 2007-10-31
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no literature reporting the application of wogonin in the preparation of drugs for the treatment of digestive system tumors, especially gastric cancer.

Method used

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  • Application of wogonin in the preparing of medicine for treating gastric cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The purpose of the experiment: According to the requirements of the guiding principles of new drug preclinical research, to test whether wogonin has the growth inhibitory effect and the strength of the effect on human gastric cancer MGC803 nude mice xenografts.

[0013] Test drug: wogonin, provided by China Pharmaceutical University, before each administration, wogonin was suspended in normal saline solution.

[0014] Control drug: Paclitaxel, produced by Haikou Pharmaceutical Factory Co., Ltd., batch number: 060804. Prepare the required concentration with physiological saline before each administration.

[0015] Dosage setting: the high dose of wogonin is 50 mg / kg, the low dose of wogonin is 25 mg / kg, and the dose of paclitaxel is 10 mg / kg.

[0016] Animals: BALB / c nude mice, provided by Shanghai Slack Experimental Animal Co., Ltd. (Experimental animal production license: SCXK (Shanghai) 2003-0003; Experimental animal use license: SYXK (Su) 2002-0053). Age: 35-40 day...

Embodiment 1

[0030] Take 10 g of wogonin, add appropriate auxiliary materials for injections (including freeze-dried powder injections and sterile subpackaged dry powder injections), and prepare anti-gastric cancer drug injections according to the injection (including freeze-dried powder injections and sterile subpackaged dry powder injections) process.

Embodiment 2

[0032] Take wogonin 10g, add suitable auxiliary materials for tablets (including sustained and controlled release tablets, matrix tablets, coated tablets, dispersible tablets, etc.), press the tablet (including sustained and controlled release tablets, matrix tablets, coated tablets, dispersible tablets, etc.) ) process to prepare anti-gastric cancer drug tablets.

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Abstract

The invention discloses an application of wogonin to prepare stomach cancer medicine in pharmacy domain, which is characterized by the following: possessing distinctive growth inhibitory action of the wogonin for human stomach cancer MGC803 bare mouse transplanting tumor. This invention provides better choice for stomach cancer patient.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to the new application of wogonin, in particular to the application of wogonin in the preparation of medicine for treating gastric cancer. Background technique [0002] Wogonin is a flavonoid compound contained in the roots of the plant Scutellaria baicalensis Georgi of the Labiatase family and various plants of the same genus, and has a structure of formula (1). [0003] [0004] Formula 1) [0005] Studies have shown that wogonin has a variety of pharmacological effects, including antioxidant, anticoagulant, antispasmodic, antibacterial, antiviral, and diuretic effects. The latest research shows that wogonin can also inhibit the proliferation of tumor cells. Reports have shown that wogonin can inhibit the proliferation of ovarian cancer A2780 cells and induce apoptosis, and its anti-tumor mechanism is related to the induction of apoptosis. A2780 apoptosis...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P35/00
Inventor 尤启冬赵卿郭青龙张海伟杨莉
Owner CHINA PHARM UNIV
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