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Medicinal composition containing red sage root and storax, preparation method and preparation

A composition, the technology of styrax, is applied in the direction of drug combination, medical preparations containing active ingredients, medical preparations with non-active ingredients, etc., which can solve the problems of fewer types of membrane materials, obstacles to ultrafiltration technology, and rising costs.

Active Publication Date: 2011-10-05
TIANJIN TASLY PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (1) The composition of Chinese herbal medicine is complex, especially in many compound preparations, the active ingredients are not fully clear, so it is necessary to carry out very in-depth research before applying ultrafiltration technology to Chinese herbal medicine preparations
For example, due to the complexity of the ingredients, it is impossible to apply ultrafiltration to the production of most traditional Chinese medicine preparations before a large number of pharmacological and clinical research tests are conducted to fully evaluate the effect of ultrafiltration on the efficacy of each ingredient in traditional Chinese medicine preparations.
[0006] (2) There are few types of membrane materials, the membrane pore size distribution is wide, and the performance is not stable
Hydrophilic membrane materials such as cellulose acetate and sulfonated polysulfone have less adsorption of solutes and a smaller molecular weight cut-off, but poor thermal stability, mechanical strength, chemical resistance, and bacterial erosion resistance are usually not high; polysulfone and other hydrophobic Membrane material has high mechanical strength, high temperature resistance, solvent resistance, and biodegradation resistance, but because the molecular chain contains a large number of hydrophobic genes or chain links, and has a lot of electrostatic charges, the membrane has a low water permeability and low anti-pollution ability
[0007] (3) Membrane fouling is the biggest obstacle preventing ultrafiltration technology from laboratory research to industrial application stage
In the ultrafiltration process of traditional Chinese medicine preparations, if the pretreatment effect of the liquid medicine is not good, the membrane surface will be easily polluted and the membrane pores will be blocked, which will reduce the permeation flux, that is, the productivity, or even fail to work normally, reduce the production efficiency, and increase the cost, resulting in membrane shortened service life
[0008] (4) The selection method of membrane modules has not yet been established, and the operating parameters of ultrafiltration still need to be optimized
[0009] Regarding the practical application of preparing compound salvia miltiorrhiza by ultrafiltration, there are few reports in the current literature, especially, utilizing ultrafiltration to carry out industrial production has always been a technical problem in this field

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  • Medicinal composition containing red sage root and storax, preparation method and preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] The raw material medicine adopts 375g of salvia miltiorrhiza, 118g of safflower, 8g of borneol, and 80g of ginseng.

[0070] Extracting the salvia miltiorrhiza and ginseng with ethanol to obtain ethanol extracts of the salvia miltiorrhiza and ginseng, filtering the extract with gauze, and collecting the filtrate. The filtrate was ultrafiltered with a cellulose diacetate membrane with a molecular weight cut-off of 6000, and the filtration method was cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.1Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.5kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are used, and the pressure fluctuation difference is 0.1Mpa. The flow rate of the fe...

Embodiment 2

[0073] The raw material medicine adopts 465g of salvia miltiorrhiza, 30g of safflower, 8g of borneol, and 50g of ginseng.

[0074] Using 70% ethanol to extract the salvia miltiorrhiza and ginseng to obtain ethanol extracts of the salvia miltiorrhiza and ginseng, microfilter with a ceramic membrane, and collect the filtrate. The filtrate was ultrafiltered with a polysulfone membrane with a molecular weight cut-off of 80,000, and the filtration method was dead-end filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.5Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.25kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the fe...

Embodiment 3

[0077] The raw material medicine adopts 260g of salvia miltiorrhiza, 165g of safflower, 7g of borneol, and 120g of ginseng.

[0078] Extract the salvia miltiorrhiza, safflower and ginseng with 30% ethanol to obtain an extract, centrifuge the extract at high speed and separate the supernatant. The liquid is ultrafiltered with a sulfonated polysulfone membrane with a molecular weight cut-off of 50,000, and the filtration method adopts cross-flow filtration. The operating conditions of the ultrafiltration process are: the pressure of the liquid inlet of the ultrafiltration is 0.35Mpa, and the pressure of the liquid outlet of the ultrafiltration is 0.20kPa lower than the pressure of the liquid inlet. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m / ...

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Abstract

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared from root of red rooted saliva, safflower, ginseng, baras camphor or liquidambar orientalis mill as the raw materials, and the preparation process comprises the steps of mixing red-rooted salvia, safflower and ginseng to obtain water extract or alcohol extract, subjecting the extract topreliminary settlement treatment, further subjecting the extract to ultrafiltration treatment, concentrating the ultrafiltrate, charging baras camphor or liquidambar orientalis mill, and producing preparation through the conventional process. The raw materials herb of ginseng can be substituted by Codonopsis pilosula.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition prepared by an ultrafiltration process. Specifically, the present invention relates to a traditional Chinese medicine composition for treating cardiovascular diseases. Background technique [0002] Membrane separation technology (Membrane Separation Technique) is a new high-efficiency separation technology, which has been internationally recognized as the most promising major high-tech production technology from the end of the 20th century to the middle of the 21st century. Ultrafiltration (UF) technology is a membrane separation technology whose basic principle is to use the selective screening performance of membrane pores to separate, purify and concentrate substances. The ultrafiltration method uses an anisotropic membrane (that is, an asymmetric membrane) made of polymer materials as the filter medium. Under normal temperature conditions, relying on a certain pressure and flow ra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/20A61K47/36A61P9/10A61K31/045
Inventor 李旭郑永锋范立君
Owner TIANJIN TASLY PHARMA CO LTD