Honeysuckle extract and its preparation method and application

A honeysuckle extract and technology of honeysuckle, applied in the field of disease medicines and health products, and pharmaceutical compositions containing the extract, can solve problems such as difficulty in industrial production, difficulty in identification, and high water solubility

Active Publication Date: 2007-12-12
HANKANG BIOCHEMICAL & PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, due to the high polarity and high water solubility of iridoids in honeysuckle and its base plant Lonicera or other plants of the same genus, conventional separation techniques are used to enrich high-content iridoids (total content greater than 50%) , especially the high content of open-linked garynylic acid is more difficult; at the same time, due to the special structure of open-linked garynylic acid, it is quite difficult to identify it. Therefore, so far, there has been no extraction from the above-mentioned plants There are no reports on eff...

Method used

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  • Honeysuckle extract and its preparation method and application
  • Honeysuckle extract and its preparation method and application
  • Honeysuckle extract and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] (1) Extraction: Take the honeysuckle medicinal material (500g), coarsely crush it, add water to soak and extract 3 times, each time the water consumption is 12 times the dry weight of the honeysuckle medicinal material, and soak for 24 hours each time. The extracts were combined, concentrated under reduced pressure to a thick extract, 500 ml of distilled water was added, heated to dissolve, cooled to room temperature, allowed to stand for 24 hours, and filtered to obtain a clear filtrate.

[0074] (2) Refining by alcohol precipitation: extract the concentrated liquid of honeysuckle with water, add ethanol (95%) under sufficient stirring to make the solution contain 70% alcohol, let stand for 24 hours, filter, collect the filtrate, and then recover the ethanol under reduced pressure to Flow extract paste.

[0075] (3) Chromatographic purification of macroporous adsorption resin: add 500 ml of the liquid extract in (2), dissolve and filter, and pass the filtrate through the p...

Embodiment 2

[0078] (1) Extraction: Take honeysuckle medicinal material (500g), coarsely crush, add water and decoct twice, each time the water consumption is 12 times of the dry weight of honeysuckle medicinal material, the decoction temperature is 98℃, and the decoction time is 1 hour each time; The water extracts were combined, filtered, and the filtrate was concentrated under reduced pressure to 1 g crude drug / mL.

[0079] (2) Refining by alcohol precipitation: extract the concentrated liquid of honeysuckle with water, add ethanol (95%) under thorough stirring to make the solution alcohol content 75%, let stand for 16 hours, filter, collect the filtrate, and then recover the ethanol under reduced pressure to Flow extract paste.

[0080] (3) Chromatographic purification of macroporous adsorption resin: add 500 ml of the liquid extract in (2), dissolve and filter, and pass the filtrate through the pretreated styrene-type macroporous adsorption resin D-101, and use 5 times the amount in turn ...

Embodiment 3

[0083] (1) Extraction: Take the honeysuckle medicinal material (500g), coarsely crush it, add water to soak and extract twice, each time the water consumption is 12 times the dry weight of the honeysuckle medicinal material, and soak for 18 hours each time. The extracts were combined, concentrated under reduced pressure to a thick extract, heated to dissolve with 500 ml of distilled water, cooled to room temperature, allowed to stand for 18 hours, and filtered to obtain a clear filtrate.

[0084] (2) Refining by water precipitation: extract the concentrated liquid of honeysuckle in water, concentrate it to dryness under reduced pressure, add 1500 ml of ethanol (95%), stir to dissolve, and slowly add distilled water to make the solution alcohol content 75%, let stand for 24 hours , Filter, collect the filtrate, and then recover the ethanol under reduced pressure to a liquid extract.

[0085] (3) Chromatographic purification of macroporous adsorption resin: add 500 ml of the liquid ...

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Abstract

The invention relates to a method for preparing plant extract from Chinese traditional medicine honeysuckle (Lonicera japonica Thunb.) or honeysuckle or other plants of same congenic strains, the honeysuckle extract and medical compound containing said extract. The effective component of said compound is secologanic acid and its derivants. The method comprises following steps: extracting with water or alcohol, depositing extract, refining through chromatogram, purifying with chromatogram if needed, getting extract with secologanic acid and its derivants concentration being more than 50%, or about 70% if better. The honeysuckle extract is characterized by analgesic, analgesic, analgesic, anti-biotic and antiviral function, and can be used to treat analgesic, pain, infectious disease, especially to treat atypical pneumonia, viral influenza and AIDS.

Description

Technical field [0001] The present invention belongs to the technical field of natural medicine. Specifically, the present invention relates to a plant extract obtained by extracting and refining from the Chinese medicine honeysuckle or its base source plant Lonicera japonica or plants of the same genus, and an extraction method thereof, and a pharmaceutical composition containing the extract. The extract obtained by the method of the present invention mainly contains acetoside acid (secologanic acid) and its derivatives, i.e. iridoid glycosides, or total iridoids Terpene glycosides. The plant extract has antipyretic, analgesic, anti-inflammatory, antibacterial and antiviral effects. The extract and the pharmaceutical composition containing the extract can be used to prepare and treat hyperthermia, pain, and infectious diseases, especially for Medicines and health products for the treatment of viral pneumonia, viral influenza and AIDS. In addition, the Kailian fenmoside acid and i...

Claims

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Application Information

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IPC IPC(8): C07H17/04A61K31/7042A61K36/355A61P31/04A61P29/00A61P31/12
Inventor 石建功李帅王素娟杨永春安玉伟韩丰年
Owner HANKANG BIOCHEMICAL & PHARMA CO LTD
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