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Visual analyzing and displaying method used for chip data analysis

A data analysis and chip technology, applied in the fields of electrical digital data processing, special data processing applications, character and pattern recognition, etc., can solve problems such as difficulty in revealing the inside, inability to express data structures and patterns, disorganized, etc., and is easy to popularize. and the effect of popularization

Inactive Publication Date: 2008-01-02
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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Problems solved by technology

These tools are quite useful in some cases, but when faced with extremely large microarray data sets, they are somewhat powerless and cannot reveal all the underlying structures and patterns in the data.
Because these commonly used tools are not specifically designed to solve the problem of large-scale chip data analysis, they have many insurmountable defects. For example, heat maps (Heat Maps) are widely used in the financial and life science fields of the industry. Based on the method of hierarchical clustering to display each data point in the data set, the color is used to indicate whether it is the up-regulation or down-regulation of a specific gene, so that when there are many data samples, there will be thousands of nodes in the dendrogram, which is very eye-catching. feel too much
The application of parallel coordinates (ParallelCoordinates) on large-scale data sets is messy, and it is difficult to reveal the inner

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  • Visual analyzing and displaying method used for chip data analysis
  • Visual analyzing and displaying method used for chip data analysis
  • Visual analyzing and displaying method used for chip data analysis

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Embodiment Construction

[0043] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0044] Fig. 1 shows the overall flow of the method of the present invention. Please refer to Figure 1, the following is a detailed description of each step in the process.

[0045] Step S1: the first time using the self-organizing map (Self-Organizing Map, SOM) neural network to simulate and learn the chip data. This technology uses simulated neurons (neurons) to replace the original data, and is based on a neural network algorithm called non-supervised (Non-supervised) self-organizing network mapping, which simulates brain neuron cells in the brain. The projection can achieve the purpose of reducing data density and data noise, and also makes subsequent data display easier.

[0046]Fig. 2 shows the sub-flow of this step. Please refer to FIG. 2, the following steps S11-S16 are detailed descriptions of these sub-processes.

[0047] Step S11: Construc...

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Abstract

The invention discloses a kind of visual analysis and exhibition method for gene chip data, and it can provide intuitionistic visual method for chip, and it can exhibit large chip data. The technical project is: the method includes: (1)using the self-organized mapping NN to stimulate and study the chip data at first time; (2)using the composing planes to exhibit the data of single chip / sample obtained at step (1), the single component of multi-dimensional nerve carrier is separated, and at the same time, it uses the two-dimensional plane to exhibit the data structure obtained at step (1); (3)it uses the self-organized nerve network to study the relationship between several samples, and projects the relationship of group planes / samples to two-dimensional space using the optimized matching principle, and exhibit the relationship between the samples and the genes. The invention can be used in the data analysis technical field of large gene chip.

Description

technical field [0001] The invention relates to a data display method for gene chip data analysis, in particular to a visual analysis and display method in large-scale gene chip data set analysis. Background technique [0002] The emergence of gene chips is a major development with great characteristics of the times in the field of high-tech in recent years. It is a high-tech formed by the comprehensive intersection of physics, microelectronics and molecular biology. Gene chip technology is a high-throughput technology. Its basic principle is to integrate tens of thousands of DNA probes on a centimeter-square chip through micro-processing technology to achieve efficient and rapid quantitative detection of mRNA and DNA sequences. In application fields such as the elaboration of gene functions, the exploration of disease causes and mechanisms, the discovery of possible diagnostic and therapeutic targets, gene chips are being used more and more. [0003] With the advancement o...

Claims

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Application Information

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IPC IPC(8): G06F19/00G06F17/00
CPCG06K2209/07G06K9/00G06V2201/04G06V10/82
Inventor 金刚王超谢松旻
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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