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Method of removing leukocyte

一种白血球、血液的技术，应用在分离方法、化学仪器和方法、滤血等方向，达到缩短过滤时间、降低血液回收不良的效果

Inactive Publication Date: 2008-01-02
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this requirement has not been recognized in the prior art
Therefore, there is no filter that has excellent performance under both room temperature filtration and cold storage filtration, and a leukocyte removal method using such a filter is still unknown

Method used

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  • Method of removing leukocyte
  • Method of removing leukocyte

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Made of polyethylene terephthalate (hereinafter abbreviated as "PET"), with an average fiber diameter of 3.9 μm and a weight per unit area (Metsuke) (weight per unit filtration area) of 60 g / m 2 , The specific surface area is 0.7m 2 / g of non-woven fabric A 1 As filter material A, use an average fiber diameter of 1.2 μm and a weight per unit area of ​​40 g / m 2 , The specific surface area is 1.5m 2 / g of PET non-woven fabric B 1 as filter material B. The specific surface area of ​​each filter material was determined by measuring the surface area of ​​0.3 g of the filter material using a specific surface area meter (SHIMADZU Micromeritics TriStar). The effective filter area is 1.33cm 2 In the column, the filter material A with a filling weight of 8.0 mg (the weight of the filter material used hereinafter means the filling weight of the effective filtering part) is filled in layers. 1 and filter material B with an effective filter portion filling weight of 58.5mg 1 ...

Embodiment 2

[0071] Use an average fiber diameter of 2.5μm and a weight per unit area of ​​60g / m 2 , The specific surface area is 0.8m 2 / g of PET non-woven fabric A 2 As filter material A. Use an average fiber diameter of 1.2μm and a weight per unit area of ​​40g / m 2 , The specific surface area is 1.5m 2 / g of PET non-woven fabric B 1 as filter material B. Pack 8.0 mg of filter material A in layers in the column described above 2 and 58.5 mg of filter material B 1 , filter material A 2 Set on filter material B 1 upstream. filter material B 1 The average fiber diameter of the filter material A 1 48.0% of the average fiber diameter, and effectively filter part of the filter material A 2 The weight sum of filter material B 1 13.6% by weight. Filtering performance of the filter was evaluated in the same manner as in Example 1. The filtration time and leukocyte removal performance during room temperature filtration were 27.6 minutes and 3.0, respectively, and the filtration time...

Embodiment 3

[0073] Use an average fiber diameter of 2.1μm and a weight per unit area of ​​60g / m 2 , The specific surface area is 0.9m 2 / g of PET non-woven fabric A 3 As filter material A. Use an average fiber diameter of 1.0μm and a weight per unit area of ​​40g / m 2 , The specific surface area is 1.8m 2 / g of PET non-woven fabric B 2 as filter material B. Pack 8.0 mg of filter material A in layers in the column described above 3 and 58.5 mg of filter material B 2 , so that the filter material A 3 Set on filter material B 2 upstream. filter material B 2 The average fiber diameter of the filter material A 3 47.6% of the average fiber diameter, and effectively filter part of the filter material A 3 The weight sum of filter material B 2 13.6% by weight. Filtering performance of the filter was evaluated in the same manner as in Example 1. The filtration time and leukocyte removal performance during room temperature filtration were 30.8 minutes and 3.2, respectively, and the fil...

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PUM

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Abstract

A method of removing leukocytes that through reducing of clogging of a leukocyte removing filter element by blood cell components and plasma proteins being a problem encountered at the time of removing leukocytes from blood, shortens the filtration time at refrigerated filtration and exhibits high leukocyte removing performance at room temperature filtration. There is provided a method of removing leukocytes including filtering blood containing leukocytes through a leukocyte removing filter apparatus having multiple fibrous filter elements with different average fiber diameters to thereby remove leukocytes from the blood, characterized in that use is made of a leukocyte removing filter apparatus wherein the multiple fibrous filter elements include at least leukocyte removing filter element (A) of 2.0 to <4.0 [mu]m average fiber diameter and leukocyte removing filter element (B) of 0.7 to 1.2 [mu]m average fiber diameter and wherein the filter element (B) is disposed downstream of the filter element (A), the leukocyte removing filter element (B) having an average fiber diameter of >17.5% to <50% of that of the filter element (A).

Description

technical field [0001] The present invention relates to a leukocyte removal filter and a leukocyte removal method for removing fine aggregates and leukocytes or leukocytes and platelets in blood. More particularly, the present invention relates to a leukocyte removal filter and a leukocyte removal method for removing microscopic aggregates and leukocytes that may cause side effects of transfusion in whole blood products, red blood cell products, platelet products, plasma products, etc. for blood transfusion. In particular, the present invention relates to a leukocyte removal filter and a leukocyte removal method that exhibit excellent filtration performance under both room temperature filtration and refrigerated filtration. Background technique [0002] In recent years, in the field of blood transfusion, a leukocyte-removed blood transfusion method in which leukocytes are removed from a blood product and then a leukocyte-depleted blood product is transfused has been widely u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/14A61M1/02A61M1/16A61K35/15A61M1/34A61M1/36B01D39/16
CPCA61M2202/0439A61M1/3636A61M1/3633A61M5/165A61M2202/005A61M1/34A61M1/02
Inventor 小林健次
Owner ASAHI KASEI MEDICAL CO LTD
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