Anthelmintic composition

Abstract

A topical formulation comprising as active ingredients, at least one effective agent derived from Streptomyces avermitilis, i.e. a macrocylic lactone e.g. an avermectin or chemically modified or synthetic derivative thereof, e.g. ivermectin, together with another anthelmintic of the sulphonamide type, e.g. clorsulon, in a carrier that facilitates topical administration and delivery of the active ingredients transdermal Iy, e.g. a carrier that is useful for this purpose comprises alcoholic solvents, such as ethanol, and isopropanol, with optional excipients and formulation aids, which may comprise a polymeric species such as PVP or a poloxamer.

Description

technical field

[0001] The present invention relates to a composition effective against Fasciola hepatica, Ostertagia ostertagi, Cooperia oncophora infections in susceptible ruminants, especially cattle. Background technique

[0002] Infection with Fasciola hepatica, Osteria austeni, and Cooperia syringae in livestock is an unresolved problem, especially in spring grazing cattle that are susceptible to infection on contaminated pastures. Injections containing ivermectin and Clorsulon are currently known methods of treatment for beef cattle and non-lactating cattle.

[0003] Closulone, a compound belonging to the benzenesulfonamide family, is recommended for the control of adult liver flukes in cattle as an oral suspension or as a subcutaneous injection. The oral dose is 7 mg / kg body weight (bw), and the subcutaneous injection is 2 mg / kg body weight. Currently, topical agents have not been developed, probably because closulone does not penetrate the skin well.

[0004] An ...

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