Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response
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A technology of molecular patterns and compositions, applied in the field of fusion proteins and polypeptides, and fusion proteins, can solve problems such as inferior immunogenicity, unknown harmful side effects, etc., and achieve effective immunogenicity, reduce side effects, and prevent or treat infections.
Inactive Publication Date: 2008-01-23
VAXINNATE
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However, such compositions may be less than optimally immunogenic, may caus
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[0229] Materials and methods
[0230] PCR amplification and DNA primers:
[0231] All PCR amplifications were performed using Pfu UltraHotstart PCR master mix (Cat# 600630) from Stratagene (La Jolla, CA) according to the manufacturer's recommendations. DNA primers were purchased from Sigma Genosys and are described below:
[0232] STF28BGF-1:
[0233] CTCGGGAGATCTGCACAAGTAATCAACACTAACAGTCT (SEQ ID NO: 41)
[0234] STF28MCR-1:
[0235] CCATGGGCTAGCAGGATCCACCGGCGCTCCCTGCACGTTCA (SEQ ID NO: 42)
[0236] STF28MCF-2:
[0237] GGAGCGCCGGTGGATCCTGCTAGCCCATGGACCGAAAACCCG (SEQ ID NO: 43)
[0238] STF28ECR-2:
[0239] TCTGCAGAATTCACGTAACAGAGACAGCACGTTCTGCGGGACGTCCCGCAGAACGTGCTGTCTCTGTTACGTGAATTCTGCAGA (SEQ ID NO: 44)
[0242] CAATTGACCTTCAAGCTTCGAATTGCCCTTACGTAACAGAGACAGCACGTTCTG (SEQ ID NO: 46)
[0243] AX-E3F3:
[0244] AAGCTTGAAGGTCAATTGGAATTCCCTAGGACTAGTATGGAAAAATTGCAGTTGAAG (SEQ ID NO: 47)
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Abstract
Compositions comprise at least a portion of an antigen and at least a portion of a flagellin that lacks a hinge region. Compositions, fusion proteins and polypeptides comprise at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one viral protein. The viral protein of the compositions, fusion proteins and polypeptides of the invention are flaviviral proteins, including a West Nile flaviviral protein, a Dengue flaviviral protein, a Langat flaviviral protein, a Kunjin flaviviral protein, a Murray Valley encephalitis flaviviral protein, a Japanese encephalitis flaviviral protein, a Tick- borne encephalitis flaviviral protein, a Yellow fever flaviviral protein and a hepatitis C flaviviral protein. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject.
Description
[0001] related application [0002] This application claims U.S. Provisional Application Nos. 60 / 645,170, filed January 19, 2005; 60 / 653,405, filed February 15, 2005; 60 / 704,160, filed July 29, 2005 ; No. 60 / 723,409, dated October 4, 2005; and No. 60 / 725,919, dated October 11, 2005. The teachings of the above applications are incorporated herein by reference. Background technique [0003] Infection with viruses including Flaviviruses, e.g., West Nile Flavivirus, Dengue Flavivirus, Japanese Encephalitis Flavivirus, Langat Flavivirus, Kunjin Flavivirus , Murray Valley encephalitis flavivirus, tick flavivirus and yellow fever flavivirus can cause severe illness and possibly death. Mosquitoes and ticks transmit many types of flaviviruses. For example, severe symptoms of West Nile virus infection include high fever, headache, stiff neck, trance, disorientation, lethargy, tremors, convulsions, muscle weakness, vision loss, numbness, meningoencephalomyelitis, and paralysis. These...
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