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Antibiotic compound containing aminoglycoside antibiotic

A technology of aminoglycosides and antibiotics, which can be used in medical preparations containing active ingredients, antibacterial drugs, anti-infective drugs, etc., and can solve problems such as reducing titer.

Active Publication Date: 2008-02-27
ガンゾウ ヘメイ ファーマスーティカル カンパニー リミテッド
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since β-lactam antibiotics are acidic compounds, and aminoglycoside antibiotics are alkaline substances, when these two types of antibiotics are used together in the same container, they will form a precipitate due to the formation of salt, or aminoglycoside antibiotics will Amino groups react with the β-lactam in β-lactam antibiotics to greatly reduce the potency of the two. Therefore, it is generally forbidden to use these two types of antibiotic solution preparations in the same container clinically.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Recipe: cefoperazone sodium 4g, gentamicin sulfate 80mg / 2mL injection.

[0071] Preparation method: Dissolve cefoperazone sodium in 200mL water for injection, add gentamicin injection, and a large amount of white precipitate will be produced immediately.

Embodiment 2

[0073] Dissolve 40 mg of cefoperazone sodium and 0.01 mg of disodium EDTA in 2 mL of buffer solutions of various pH values ​​and strengths, and drop into 20 μL of gentamicin 80 mg / 2 mL injection. Sonicate for 5 minutes to observe whether there is precipitation. The result is that no precipitation is formed when the pH value of the buffer is above 6, and a clear solution can be obtained. The type of buffer has little effect on the result. The results are shown in the table.

[0074] Type of buffer

[0075] * The solution becomes slightly cloudy ** the solution becomes cloudy *** The solution is cloudy OK clear liquid

Embodiment 3

[0077] Cefoperazone sodium 40mg, EDTA disodium 0.01mg and sulbactam sodium 5mg were dissolved in 2mL of various buffer solutions with different pH values ​​and strengths, and 20μL of gentamicin 80mg / 2mL injection was added dropwise. Sonicate for 5 minutes to observe whether there is precipitation. The result is that there is no precipitation when the pH value of the buffer is above 6 and the strength is above 20mM, and a clear solution can be obtained. The type of buffer has little effect on the result. The results are shown in the table.

[0078] Type of buffer

[0079] * The solution becomes slightly cloudy ** the solution becomes cloudy *** The solution is cloudy OK clear liquid

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PUM

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Abstract

The invention discloses an antibiotic compound, which comprises the following parts: at least one aminoglycoside antibiotics, at least one ion chelant to inhibit the generation of particle or at least one buffer component or at least one ion chelant and at least one buffer component. The compound can build with at least one beta-lactam antibiotics in the same container to form the solvent to as the drug to control microbe infection or build with at least one beta-lactam antibiotics and at least one beta-lactamase inhibitor in the same container to form the solvent to as the drug to control microbe infection.

Description

Field of invention: [0001] The invention discloses an antibiotic compound composed of at least one aminoglycoside antibiotic and at least one ion chelating agent capable of inhibiting particle formation or at least one buffer component or simultaneously adding at least one ion chelating agent and at least one buffer component , the compound is characterized in that it can be formulated into a stable solution preparation, and can be formulated into a solution preparation in the same container with at least one β-lactam antibiotic as a drug for controlling microbial infections, or combined with at least one β-lactam antibiotic The compound preparation of lactam antibiotics and at least one β-lactamase inhibitor is compounded into a solution preparation in the same container and used as a drug for controlling microbial infection. technical background: [0002] Aminoglycoside Antibiotics are glycosides formed from amino sugars (monosaccharides or disaccharides) and aminocyclitol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/545A61K31/43A61K31/7036A61K47/18A61K9/08A61K9/19A61P31/04
CPCA61K9/0019A61K9/19A61K31/545A61K31/7036A61K47/12A61K31/43A61K47/183A61P31/00A61P31/04A61P43/00
Inventor 张和胜
Owner ガンゾウ ヘメイ ファーマスーティカル カンパニー リミテッド
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