Scutellaria barbata total flavone and its application in preparing influenza virus resisting medicine

Abstract

The invention relates to total flavone of barbat skullcap and new usage in the preparation of anti-influenza virus drug, belonging to the field of traditional Chinese medicine. The total flavone of barbat skullcap of the invention is total flavone extract which is separated and extracted from the dry aerial part of barbat skullcap which belongs to labiatae scutellaria plant and grows in China. Tested by mass spectrum and <13>C, <1>H, the total flavone extract of barbat skullcap contains active chemical component 5, 7, 4'-tri-hydroxyl flavone (apigenin) of the following chemical structure. The total flavone extract is tested by in vitro cell model and in vivo animal model and proved to have strong activity of anti-influenza virus. The total flavone extract and active component apigenin can be further prepared into anti-influenza virus drug and the dosage forms can be capsules, tablets, granules, and injection and the like.

Description

technical field The invention belongs to the field of traditional Chinese medicine and relates to an anti-influenza virus drug, in particular to total flavonoids of Scutellaria barbata and its new application in the preparation of anti-influenza virus drug. Background technique: Scutellaria barbata is the dried whole herb of Scutellaria barbate, a plant of the genus Scutellaria barbate in the Lamiaceae family. It is mainly produced in Jiangsu, Jiangxi, Fujian, Guangdong and other places in my country, and its resources are relatively abundant. Its main components are flavonoids, diterpenes and diterpene lactones, polysaccharides, and abundant trace elements necessary for the human body. Traditional Chinese medicine believes that Banzhilian is pungent, bitter, and cold, and enters the lungs, liver, and kidneys. It can clear away heat and detoxify, remove blood stasis and diuresis. Bruises. Scutellaria barbata has been widely used in traditional Chinese medicine, and there ...

AI Technical Summary

Problems solved by technology

Taking a comprehensive view of the reports both at home and abroad, there is no anti-influenza virus efficacy of the total flavonoid extract of the dry aerial part of Banzhilian (Scutellaria barbate) and the medicine prepared therefrom.