Transdermal method and patch for nausea
A skin-to-skin contact technology, applied in medical science, bandages, etc., can solve problems such as lack of penetration enhancers
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0083] Example 1: Preparation of Adhesive Mixture and Transdermal Delivery Device
[0084] Table 1:
[0085] combination
Formula A
Formula B
patch size
15.0cm 2
15.0cm 2
Estimated target daily dose
1.2mg
1.2mg
Dry%
Dry%
Styrene-butadiene rubber
44.04
--
Acrylate-vinyl ethyl
Ester Pressure Sensitive Adhesives
--
43.8
Isopropyl myristate
3.01
4.07
granisetron base
3.05
3.05
35.8
35.8
polyester mat
13.3
13.3
[0086] components
[0087] Formulation A and Formulation B were formulated using the amounts of each component in Table 1 above.
[0088]The styrene-butadiene rubber pressure sensitive adhesive used in this example was DURO-TAK(R) 87-6173 adhesive, available from National Starch and Chemica...
Embodiment 2
[0094] Example 2: Flow testing of granisetron base from a transdermal delivery device
[0095] step
[0096] Thermally isolated human cadaver skin was cut to the desired size and mounted on Franz diffusion cells. The release liner was peeled from the patch prepared according to Formulation B described in Example 1 above. Place the patch on the skin and press the patch and skin together. Add receptor solution to spreading cells and maintain assembly at 32 °C. At regular intervals (24 hours, 48 hours, 72 hours, 96 hours, and 120 hours) measured amounts of receptor solution were withdrawn. The concentration of granisetron in the receptor solution was measured at each moment and the flow rates in samples A and B were calculated. The resulting data are shown in Figure 1. Similarly, the cumulative delivery of granisetron over the indicated times was calculated from the concentration of granisetron in the receptor solution at each moment and is shown in FIG. 2 .
Embodiment 3
[0097] Example 3: Stability of Granisetron in Example Examples
[0098] Table 2:
[0099] combination
[0100] Using the formulations in Table 2, patches were prepared according to the procedure described in Example 1. The patches were then tested for granisetron stability using the method described below.
[0101] Patch samples were stored at 50 °C for up to 2 months. The stability of the product is evaluated by periodically testing the granisetron content and the total amount of impurities with high performance liquid chromatography. The results are shown in Table 3 below.
[0102] table 3:
[0103] time
[0104] The data in Table 3 show that in the compositions of the examples of the present invention, granisetron remains stable at 50° C. for at least 2 months, relative to the initial time T 0 When formulated, there is only a small amount of potency loss and a small amount of impurities.
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More