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Physical cross-bonding high molecular water resin Cataplasma substrate and preparing method thereof

A physical cross-linking and polymer technology, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulas, sheet-like transportation, etc., to achieve high moisture content, easy to carry and use, and good air permeability

Inactive Publication Date: 2008-06-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The physically cross-linked polymer hydrogel poultice matrix is ​​prepared by adding a cross-linking agent to physically cross-link at room temperature because the main material of the matrix—the polymer is dissolved and mixed with drugs and other auxiliary materials evenly. Therefore, it has little effect on the chemical properties and mixing uniformity of the added drug and other excipients, the pH value of the matrix is ​​easy to control and adjust, the matrix can be directly coated on the non-woven fabric, and the physical crosslinking process is in the coating process The cross-linking speed is easy to control, the whole production process can be carried out continuously, and the production efficiency is high. However, because the main material of the matrix-high molecular polymer has a process of re-dissolving, there are still some problems in the dissolution process. and trouble

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Preparation of solution A: Slowly drop 10.9 milliliters of sodium hydroxide solution (0.22 g / ml) into 8.67 grams of acrylic acid at 0°C to react and keep stirring to make it fully react. After the reaction is complete, add 0.01 grams of potassium persulfate and 1.6 ×10 -2 gram of tetramethylethylenediamine was stirred uniformly and then added water to the solution quality to 100 grams in the solution obtained after stirring, and the solution A was obtained after stirring;

[0026] (2) Prepare solution B: heat solution A at 55 degrees Celsius for 2 hours to obtain solution B;

[0027] (3) Prepare solution C: mix 10 grams of glycerin, 0.5 grams of tartaric acid and 9.5 grams of water, add 80 grams of solution B and stir evenly to obtain solution C;

[0028] (4) Prepare thick liquid D: add 0.1 g of aluminum hydroxide to 100 g of solution C and stir well to eliminate air bubbles to obtain thick liquid D;

[0029] (5) Apply the thick liquid D on the non-woven fabric; c...

Embodiment 2

[0031] (1) Preparation of solution A: Slowly drop 19.6 milliliters of sodium hydroxide solution (0.22 g / ml) into 15.6 grams of acrylic acid at 5°C to react and keep stirring to make it fully react. After the reaction is complete, add 0.03 grams of potassium persulfate, 3.12 ×10 -2 gram of tetramethylethylenediamine was stirred uniformly and then added water to the solution quality to 100 grams in the solution obtained after stirring, and the solution A was obtained after stirring;

[0032] (2) Prepare solution B: heat solution A at 60 degrees Celsius for 3 hours to obtain solution B;

[0033] (3) Prepare solution C: mix 1.0 g of tartaric acid and 42.4 g of water, add 55.6 g of solution B and stir well to obtain solution C;

[0034] (4) Prepare thick liquid D: add 0.1 g of aluminum potassium sulfate to 100 g of solution C and stir well to eliminate air bubbles to obtain thick liquid D;

[0035] (5) Apply the thick liquid D on the non-woven fabric, cover the other side of the ...

Embodiment 3

[0037] (1) Prepare solution A: Slowly drop 32.7 milliliters of sodium hydroxide solution (0.22 g / ml) into 26.0 grams of acrylic acid for reaction at 10°C and keep stirring to make it fully react. After the reaction is complete, add 0.1 grams of potassium persulfate and 7.8 ×10 -2 gram of tetramethylethylenediamine was stirred uniformly and then added water to the solution quality to 100 grams in the solution obtained after stirring, and the solution A was obtained after stirring;

[0038] (2) Prepare solution B: heat solution A at 65 degrees Celsius for 3 hours to obtain solution B;

[0039] (3) Preparation of solution C: Mix 5.0 grams of glycerin, 1.0 grams of tartaric acid and 60.7 grams of water, add to 33.3 grams of solution B and stir well to obtain solution C;

[0040] (4) Preparation of thick liquid D: add 1.0 g of aluminum glycinate to 100 g of solution C and stir well to eliminate air bubbles to obtain thick liquid D;

[0041] (5) Apply the thick liquid D on the non...

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Abstract

The invention provides a preparation method for a substrate of physical crosslinking polymer hydrogel cataplasm. The preparation process includes the following steps: add sodium hydroxide solution in acrylic acid for reaction, then add tetramethyl ethylenediamine and potassium persulfate and stir the mixture to be even to get A solution; heat the A solution for reaction to get B solution; add glycerol and tartaric acid into the B solution and stir the mixture thoroughly to get C solution; add aluminum salt into the C solution and stir thoroughly to get condensed D solution, and finally smear the condensed D solution on a non-woven fabric and cover the non-woven fabric with an antisticking membrane. In this way the substrate of physical crosslinking polymer hydrogel cataplasm can be prepared. The invention does not affect or change the chemical properties of the added medicine, can be formed by coating and pressing and has the advantages of high moisture content rate, no stimulation to skin, good permeability and no pollution to clothes and is convenient to carry and use and can be used to prepare polymer hydrogel cataplasm-a novel formulation of plaster for external use.

Description

technical field [0001] The invention relates to a cataplasm matrix, in particular to a physically cross-linked polymer hydrogel cataplasm matrix and a preparation method thereof. Background technique [0002] There are usually two ways to prepare polymer hydrogel cataplasm: [0003] 1. When synthesizing the main material of the cataplasm - high molecular polymer, chemical cross-linking is carried out to obtain the polymer hydrogel and at the same time, the formed cataplasm is obtained. [0004] 2. Dissolving the high molecular polymer and then crosslinking (usually physical crosslinking) with a crosslinking agent to solidify and form a high molecular hydrogel, which is prepared into a poultice. [0005] When the chemically cross-linked polymer hydrogel is used to prepare the cataplasm matrix, since the matrix system needs to undergo a polymerization reaction and a chemical cross-linking process to form at one time, the chemical properties and uniform mixing of the drugs and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/30
Inventor 童真裴煜刘新星
Owner SOUTH CHINA UNIV OF TECH
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