Composite containing pioglitazone HCL and repaglinide

A technology of pioglitazone hydrochloride and a composition, applied in the field of medicine, can solve the problems such as no literature report on the compound preparation of pioglitazone hydrochloride and repaglinide, and achieve the effects of reducing the frequency of taking, simplifying the taking and use, and reducing the dosage

Inactive Publication Date: 2008-06-25
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
View PDF1 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, after searching, there is no literature report on the compound preparation of pioglitazone hydrochloride and repaglinide

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 Sustained-release tablet 1, sustained-release granule 1, sustained-release capsule 1

[0033] prescription

[0034] particle 1

particle 2

components

Dosage

components

Dosage

Pioglitazone Hydrochloride

microcrystalline cellulose

lactose

5% PVP aqueous solution

L-HPC

Magnesium stearate

Micropowder silica gel

Co-made

15g

10g

40g

Appropriate amount

2g

0.3g

0.6g

1000 pieces

repaglinide

HPMC (K15M)

HPMC

(K100LV)

microcrystalline cellulose

lactose

10% PVP water soluble

liquid

Magnesium stearate

Micropowder silica gel

Co-made

3.0g

10g

7g

9g

30g

Appropriate amount

0.25g

0.5g

1000 pieces

[0035] Preparation:

...

Embodiment 2

[0040] Embodiment 2 Sustained release capsule 2

[0041] Preparation method: compress granule 2 in Example 1 to make tablet 2; pack granule 1 in Example 1 into capsules, put it into tablet 2, and obtain it.

[0042] Granules 1 in Example 1 can also be compressed into tablets, and then put into capsules filled with Granules 2 in Example 1.

Embodiment 3

[0043] Embodiment 3 liquid capsule

[0044] prescription

[0045] components

Dosage

Pioglitazone Hydrochloride

repaglinide

Corn oil

beeswax

production

15.0g

1.5g

200g

15g

1000 capsules

[0046] Preparation:

[0047] Pass the pioglitazone hydrochloride and repaglinide through a 120-mesh sieve and set aside. Weigh the beeswax according to the prescription and add it to the corn oil, heat and stir until dissolved, add the prescribed amount of pioglitazone hydrochloride and repaglinide, mix and stir thoroughly to make a suspension, put it into a suitable capsule shell, heat seal it, and obtain it.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a composition which takes a pioglitazone hydrochloride and a repaglinide as an active ingredient and a preparation method thereof.The invention, taking the pioglitazone hydrochloride and the repaglinide as a medicinal active ingredient, is a medicinal composition mixedly formed with a carrier adoptive in pharmacy, and the invention can be prepared into oral preparations such as a troche, a capsule, a dispersible tablet, a chewable tablet, an orally disintegrating tablet, a buccal tablet, a liquid capsule, a soft capsule and a pill, etc. The composition can be used for curing type two diabetes.

Description

technical field [0001] The invention relates to a pharmaceutical composition, more specifically to an oral preparation with pioglitazone hydrochloride and repaglinide as active ingredients, and belongs to the technical field of medicine. Background technique [0002] The incidence of diabetes is still increasing year by year. China has become the hardest-hit area, and the number of diabetic patients ranks second in the world after India. According to the data provided by the World Health Organization (WHO), the prevalence of diabetes in developed countries has reached as high as 5% to 10%, and in my country it is about 3%. According to the most conservative calculation, the number of diabetic patients in China increases by one million every year. There are 2,700 new cases; by 2030, the number of diabetic patients in the world will double compared with 2000. [0003] Analysts pointed out that for some time to come, the incidence of type 1 diabetes will remain relatively stab...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/4453A61K9/20A61K9/22A61K9/48A61K9/52A61K47/34A61K47/38A61K47/44A61P3/10A61K31/4439A61K47/26
Inventor 李邦良潘福生叶杉王琼
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap