Benzydamine hcl suppository and method for preparing the same

A technology of benzydamine hydrochloride suppositories and benzydamine hydrochloride, applied in the field of medicine, to achieve the effects of improving drug safety, improving drug quality, and easy quality control

Inactive Publication Date: 2008-07-16
广西壮族自治区花红药业集团股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a treatment for bacterial vaginosis, there is no clinical research report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Embodiment 1: a kind of benzydamine hydrochloride suppository, it is made up of benzydamine hydrochloride 25 g, mixed fatty acid glyceride 1.5kg; Make 1000 suppositories.

[0099] Preparation method: proceed as follows:

[0100] a) Put 1.5kg of the above-mentioned mixed fatty acid glycerides into a water bath at 50-60°C to melt, then add the micronized raw material benzydamine hydrochloride in the proportioning ratio, stir and disperse to form a uniform suspension;

[0101] b), measure the suspension content, and calculate the filling volume;

[0102] c), after the suspension is cooled to 45°C, fill it in a plug mold;

[0103] d), after further cooling until the embolus is solidified, take it out to obtain the product.

Embodiment 2

[0104] Embodiment 2: a kind of benzydamine hydrochloride suppository, its composition is benzydamine hydrochloride 25g, mixed fatty acid glyceride 1.0kg; Make 1000 suppositories.

[0105] The preparation method is the same as in Example 1.

Embodiment 3

[0106] Embodiment 3: a kind of benzydamine hydrochloride suppository, it is made up of benzydamine hydrochloride 25g, semi-synthetic fatty acid ester 1.0kg; Make 1000 suppositories.

[0107] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention provides a benzydamine hydrochloride suppository, which is characterized in that: the suppository consists of effective doses of benzydamine hydrochloride and suppository matrix, the proportion by weight is that the ratio between benzydamine hydrochloride and suppository matrix is 1:20-100. The suppository matrix of the invention can protect effectively the active ingredient of the benzydamine hydrochloride to ensure the product of the invention to prevent the loss of the active ingredient of the benzydamine hydrochloride suppository and ensure the curative effect to be fully exerted to the utmost extent, thereby enabling the product of the invention to improve drug quality and safe application.

Description

technical field [0001] The invention relates to a benzydamine hydrochloride suppository and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Benzydamine hydrochloride is an antipyretic and analgesic drug, which has been used for many years at home and abroad. As a treatment for bacterial vaginosis, there is no clinical research report in China, but benzydamine hydrochloride lotion has been widely used abroad. Contents of the invention [0003] The object of the present invention is to provide a kind of benzydamine hydrochloride suppository which is good in curative effect for treating bacterial vaginosis and can improve drug quality and drug safety. [0004] Another object of the present invention is to provide a preparation method of the suppository. [0005] The object of the present invention is achieved like this: a kind of benzydamine hydrochloride suppository, it is characterized in that: above-mentioned suppository is...

Claims

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Application Information

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IPC IPC(8): A61K31/416A61K9/02A61P15/02A61P31/02
Inventor 王建标汪渡方霜胡显刚银媛王怡
Owner 广西壮族自治区花红药业集团股份公司
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