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Compounds for strengthening organism immunity function and application thereof

A technology of body immunity and composition, which is applied in the application field of astragalus polysaccharide and 20-protopanaxadiol combined in enhancing body immunity, can solve the complex composition of total ginsenosides that do not represent single component aglycones, not seen, and ginseng. And other issues

Active Publication Date: 2010-04-07
SHANGHAI INNOVATIVE RESEARCH CENTER OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] 20(S)-protopanaxadiol and astragalus polysaccharide can enhance the immune function of the body when used alone, but there is no report on the combination of the two
There are also reports on the combined use of astragalus polysaccharides and total ginsenosides, but the composition of total ginsenosides is complex, and its function does not represent the function of a single component aglycon

Method used

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  • Compounds for strengthening organism immunity function and application thereof
  • Compounds for strengthening organism immunity function and application thereof
  • Compounds for strengthening organism immunity function and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Add 5.0 kg of notoginseng leaf glycosides, 60 kg of n-butanol, and 6.0 kg of sodium ethoxide into the reaction kettle, stir, and feed oxygen to keep bubbles continuously emerging in the bubbling meter, raise the temperature, control the temperature at 95±5°C, and react for 72 hour, lower the temperature to 50°C, add n-butanol saturated water to wash twice, the first time is 70 kg, and the second time is 30 kg, the water layer is separated, the n-butanol layer is concentrated under reduced pressure and recovered to dryness, and n-butanol is recovered , add 50 kg of water to the residue, stir, extract three times with ethyl acetate, 25 kg, 12 kg and 12 kg respectively, discard the water layer, combine the ethyl acetate layers, wash twice with saturated brine, 15 kg each time, Separate the water layer. Add 3 kg of anhydrous sodium sulfate to the ethyl acetate layer, dry, concentrate the ethyl acetate layer to dryness under reduced pressure, recover the ethyl acetate to obt...

Embodiment 2

[0028] Materials: 20(S)-protopanaxadiol (Example 1); Astragalus polysaccharide (Shanghai Huyun Pharmaceutical Development Co., Ltd., batch number: AP070401).

[0029] Take an appropriate amount of 20(S)-protopanaxadiol, grind it, and pass through an 80-mesh sieve; take an appropriate amount of astragalus polysaccharide, grind it, and pass it through an 80-mesh sieve; take 50 grams of sieved 20(S)-protopanaxadiol, and pass through a sieve The last 10 grams of astragalus polysaccharides were mixed thoroughly and evenly according to the method of equal incremental addition.

Embodiment 3

[0031] Materials: 20(S)-protopanaxadiol (Example 1); Astragalus polysaccharide (Shanghai Huyun Pharmaceutical Development Co., Ltd., batch number: AP070401); lactose (Zhengzhou Furunde Bioengineering Co., Ltd., batch number: 55-0139) ; Povidone K30 (Zhengzhou Furunde Biological Engineering Co., Ltd., batch number: 3D070827218); sodium starch glycolate (Zhengzhou Furunde Biological Engineering Co., Ltd., batch number: 070720).

[0032] Preparation of capsules: take 20(S)-protopanaxadiol, astragalus polysaccharide, lactose, and sodium starch glycolate, sieve them separately, and set aside. Weigh each material after sieving according to the following prescription:

[0033] 20(S)-Protopanaxadiol: 50g

[0034] Astragalus polysaccharide: 10 grams

[0035] Lactose: 100 grams

[0036] Sodium starch glycolate: 5 grams

[0037] Mix well and evenly by equal volume addition method. The mixed powder is made into a soft material with an appropriate amount of povidone K30 aqueous soluti...

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Abstract

The invention provides a combination used for enhancing organism immune function. The active components of the invention are astragalus polysaccharide and 20(S)-protopanaxadiol. The combination use ofthe astragalus polysaccharide and 20(S)-protopanaxadiol can enhance the organism immune function. Pharmacological tests show that the combination use of the two components is superior to separation use of each of the two components on the function of enhancing thymus index of normal mice, the CTX of which is decreased. 20(S)-protopanaxadiol can promote the immune regulation effect of the astragalus polysaccharide.

Description

technical field [0001] The invention relates to a composition capable of enhancing the immune function of the body and its application, in particular to the application of astragalus polysaccharide combined with 20(S)-protopanaxadiol in enhancing the immune function of the body. It belongs to the field of medicine. Background technique [0002] Immunity is the process by which the body recognizes and eliminates antigenic foreign bodies in order to maintain the body's physiological balance. The human immune system has three protective functions: [0003] ①Immune defense function: resist the invasion of bacteria, viruses, fungi and other pathogens. [0004] ②Immune stabilization function: remove aging and dead cells in the body in time, so as not to hinder the normal function of the body, so as to maintain the stability of the body. [0005] ③Immune surveillance function: to detect and eliminate mutated cells in the body in time to prevent the occurrence of tumors. [0006...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K31/575A61P37/02
Inventor 惠永正王玉芹杨志奇俞春莺张文静潘欣萍葛强
Owner SHANGHAI INNOVATIVE RESEARCH CENTER OF TRADITIONAL CHINESE MEDICINE