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Preparing method of Jiaozhi soft capsule

A technology of soft capsules and pepper twigs, applied in the field of preparation of pepper twigs soft capsules, can solve problems such as uneven mixing, precipitation, and hard lumps of saponin powder, and achieve good stability

Active Publication Date: 2010-09-22
ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The saponin powder of papaya saponin has good water solubility. However, dissolving the saponin powder of paprika saponin in water and mixing it with pepper oil will easily cause the shell of the soft capsule to dissolve easily; if the pepper powder is directly mixed with the glycoside powder, it will not only mix unevenly but also The saponin powder is precipitated to cause precipitation problems. If Tween 80 is added to solubilize as usual, the saponin powder is not only insoluble but easy to form hard lumps.

Method used

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  • Preparing method of Jiaozhi soft capsule
  • Preparing method of Jiaozhi soft capsule
  • Preparing method of Jiaozhi soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: preparation of pepper eye oil

[0023] Jiaomu was purchased from Shaanxi Shenghua Pharmaceutical Co., Ltd., which was dried Dahongpao Zanthoxylum bungeanum produced in Hancheng, Shaanxi, and the peel, stem and impurities were removed; the FY221-50-06 supercritical extraction device (developed by Nantong Feiyu Petroleum Technology Co., Ltd. Ltd.) to CO 2 It is a supercritical fluid. Supercritical extraction is carried out at 30-35°C and 7.0-8.0 MPa to obtain thick yellow vegetable oil, that is, pepper oil.

Embodiment 2

[0024] Embodiment 2: preparation of saponin powder

[0025] Chonglou (purchased from Yunnan Qiancaoyuan Pharmaceutical Co., Ltd.), crushed to a coarse powder (20 mesh), added 8 times the weight of 80% ethanol, and refluxed at 70°C to 80°C for extraction; filtered, and the filtrate was adsorbed by a macroporous adsorption resin , The effluent was discarded, washed with an appropriate amount of water, and then desorbed with 70% ethanol. The ethanol was recovered from the desorbed solution, filtered, and dried to obtain a dark brown crystalline powder, which is papaya saponin powder.

Embodiment 3

[0026] Embodiment 3: soft capsule preparation

[0027] formula:

[0028] Pepper Oil 2050g

[0029] Chrysanthemum saponin powder 200g

[0030] Tween 80 20g

[0031] Made into 5000 capsules.

[0032] Process:

[0033] Weigh 2050 grams of pepper oil, stir evenly and let it stand for 24 hours, then take 500 grams of clarified pepper oil supernatant, add Tween 80 in a water bath at 45-50°C, stir in one direction, and mix evenly Immediately add saponin powder, keep stirring in the same direction, continue to stir to fully dissolve, then slowly add the remaining pepper oil to the full amount, stir while adding, until the mixture is uniform, and a uniform and fine brown mixture is obtained. Capsule contents.

[0034] The contents of the Jiaozhi soft capsules are made into soft capsules by dripping method: the contents of the Jiaozhi soft capsules are added to the hopper; ℃; put the cooling liquid that is not miscible with gelatin into the soft capsule container, and the cooling...

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Abstract

The invention provides a method for preparing Jiaozhi Soft Capsule. The main raw materials for preparing the content of the Jiaozhi Soft Capsule includes zanthoxylum seed oil and Chinese paris rhizome saponin powder, mass ratio of which is 8-15 : 1, as well as Tween 80, the mass ratio of which accounts for 0.5-2 percent of the total mass of zanthoxylum seed oil and Chinese paris rhizome saponin powder; the method includes that: zanthoxylum seed oil is stirred uniformly, stands still for delamination; the supernatant fluid of the zanthoxylum seed oil is taken, added with Tween 80, stirred to be mixed evenly, and then is added with the Chinese paris rhizome saponin powder, stirred continuously until being emulsionized and dissolved completely, and then is added with the zanthoxylum seed oilto full dose, stirred until being evenly mixed, thus getting the content of the Jiaozhi soft capsule. The content of the Jiaozhi soft capsule is prepared into the Jiaozhi soft capsule through a dropping method. The beneficial effect of the invention mainly lies in that: by adopting the method of the invention, the zanthoxylum seed oil and the Chinese paris rhizome saponin powder can be fully mixed, and the prepared Jiaozhi soft capsule has good stability; observed for more than 6 months at normal temperature, evenness and properties thereof are not affected.

Description

(1) Technical field [0001] The invention relates to a preparation method of Jiaozhi soft capsules, in particular to a preparation method of contents of Jiaozhi soft capsules. (2) Background technology [0002] Pepper order, is the dry mature seed of Zanthoxylum schinifolium Sieb.et Zucc. or Zanthoxylum bungeanum Maxim. Harvest when the fruit is ripe in autumn, dry it in the sun, and remove the peel, stalk and impurities. Unsaturated fatty acids account for 90% of the total unsaturated fatty acids (mainly α-linolenic acid) in the pepper oil extracted from pepper eyes. α-linolenic acid is an essential fatty acid for the human body, which has the functions of regulating blood lipids, anti-cancer, and improving the body's immunity, etc. It has multiple functions. In addition, pepper oil is also rich in mineral elements necessary for the human body such as Ca, Mg, Fe, Zn, Sr, Mn, etc. Therefore, pepper oil can become a rare functional edible oil and a new type of traditional Chi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61K9/48A61K47/34A61P7/10A61P11/06A61P11/14A61K47/26
Inventor 许家鸾宋康骆仙芳
Owner ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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