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Medicine compounds for treating diabetic nephropathy

A technology for diabetic nephropathy and a composition is applied in the field of pharmaceutical compositions for the treatment of diabetic nephropathy, which can solve problems such as unsatisfactory effects and inability to effectively inhibit the development of diabetic nephropathy, and achieve good therapeutic effects, synergistic effects, and rational drug use.

Active Publication Date: 2008-07-30
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of these treatment measures is not satisfactory and cannot effectively inhibit the development of diabetic nephropathy.

Method used

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  • Medicine compounds for treating diabetic nephropathy
  • Medicine compounds for treating diabetic nephropathy
  • Medicine compounds for treating diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 tablet

[0014] Prescription Bosentan 50g

[0015] Pioglitazone 10g

[0016] Microcrystalline Cellulose 100g

[0017] 8% hydroxypropyl methylcellulose solution appropriate amount

[0018] Low-substituted hydroxypropyl cellulose 50g

[0019] Magnesium Stearate 2g

[0020] Preparation process: Bosentan and piroglitazone are passed through a 100-mesh sieve, microcrystalline cellulose and low-substituted hydroxypropyl cellulose are passed through a 80-mesh sieve, and the prescribed amount of bosentan, piroglitazone and low-substituted hydroxypropyl cellulose is weighed. Mix the cellulose and microcrystalline cellulose evenly, add an appropriate amount of 8% hydroxypropyl methylcellulose solution to granulate, dry at 60°C, sieve the granules with 16 meshes, add the prescribed amount of magnesium stearate to the dry granules, mix evenly, press Slice and serve.

Embodiment 2

[0021] Example 2 tablet

[0022] Prescription Bosentan 50g

[0023] Rosiglitazone 1.5g

[0024] Microcrystalline Cellulose 100g

[0025] PEG6% solution appropriate amount

[0026] Carboxymethyl Cellulose Calcium 15g

[0027] Magnesium Stearate 2g

[0028] Preparation process: with embodiment 1.

Embodiment 3

[0029] Embodiment 3 Capsules

[0030] Prescription Bosentan 50g

[0031] Pioglitazone 20g

[0032] Pregelatinized starch 50g

[0033] Mannitol 50g

[0034] Lactose 40g

[0035] 6% PVP in 95% ethanol solution

[0036] Micronized silica gel 5g

[0037] Preparation process: pass bosentan, piroglitazone, pregelatinized starch, mannitol, lactose and micropowder silica gel in the prescription through a 100-mesh sieve, mix well, add 6% PVP in 95% ethanol solution to granulate in an appropriate amount, 60 Dry at ℃, sieve through a 18-mesh sieve, and fill the capsules.

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Abstract

The invention provides a novel medical composite for treating diabetic and nephropathy, which comprises insulin sensitizer and endothelin receptor blocker. The invention scientifically combines two medicines with complete different mechanisms of action, and reaches the target of mechanism complementation, mutual coordination, enhancing treatment effect and rational use of drug. The invention not only has good coordination in reducing blood sugar, but also achieves quite good coordination effect for protecting kidney. The invention is probably a new breakthrough of the treatment method of diabetic nephropathy.

Description

Technical field [0001] The invention relates to a new pharmaceutical composition and its preparation for treating diabetic nephropathy. Background technique [0002] Chronic complications of diabetes have gradually become the main disease that threatens the health of patients. Among them, diabetic nephropathy is one of the most serious chronic complications of diabetes; it is also one of the main causes of death in diabetic patients. According to reports, 50% of patients with type 1 diabetes died of chronic renal failure, while 5% to 10% of patients with type 2 diabetes died of renal failure. [0003] With the increase of the incidence of diabetes, the number of DN patients is increasing day by day. Because of its hidden onset and slow progress, if it is allowed to develop, when persistent proteinuria appears clinically, the kidney disease is not in the early stage, and irreversible kidney disease has appeared. , It cannot be reversed with drugs, and so far there is no eff...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/506A61K9/20A61K9/46A61P3/10A61P13/12A61K31/4439A61K31/426
Inventor 赵志全姚景春
Owner LUNAN PHARMA GROUP CORPORATION
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