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Quick acting preparations preparation for preventing and treating chronic emphraxis pulmonary disease

A technology for chronic obstructive and pulmonary diseases, applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve problems such as short curative effect, easy recurrence, and patient loss

Inactive Publication Date: 2008-08-27
JINGHUA PHARMA GRP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since COPD will permanently damage the patient's airway and lung tissue, if it is not treated in time or treated incorrectly, the result of disease progression will inevitably bring irreparable losses to the patient
[0003] Due to the complex pathogenesis of the disease, there are great limitations in the treatment of traditional Chinese and Western medicine.
Traditional Chinese medicine generally adopts the method of resolving phlegm, relieving cough and asthma, and invigorating the spleen and kidney. Most of them use Erchen Decoction, Xiaoqinglong Decoction, Jinkuishenqi Pill, etc., but the curative effect is short-lived, the cure rate is low, and it is easy to relapse; Western medicine only targets allergens. , Allergic allergies and the manifested clinical symptoms, use anti-inflammatory, anti-allergic and antispasmodic antiasthmatic methods, use aminophylline, β-receptor stimulants, anticholinergics, hormones and mediator release blockers and other drugs , they can only temporarily relieve the symptoms, and because they cannot be cured, patients have to take them for a long time, resulting in side effects such as hormone dependence, obesity, and endocrine disorders

Method used

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  • Quick acting preparations preparation for preventing and treating chronic emphraxis pulmonary disease
  • Quick acting preparations preparation for preventing and treating chronic emphraxis pulmonary disease
  • Quick acting preparations preparation for preventing and treating chronic emphraxis pulmonary disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] Take by weighing 12~20 grams of Salvia Miltiorrhiza (Example 12, 16, 20 grams), add 10~12ml (Example 10, 11, 12ml) 80%~95% (weight concentration) of ethanol as entrainer, at a pressure of 15~28mpa Carry out supercritical extraction of carbon dioxide under low temperature, and the extract is set aside. Salvia miltiorrhiza residue and golden buckwheat 5-27 grams (Example 5, 15, 27 grams), licorice 2-5 grams (Example 2, 3, 5 grams), bitter almond 6-27 grams 15 grams (Example 6, 12, 15 grams), 1-4 grams of ephedra (Example 1, 3, 4 grams), perilla 5-13 grams (Example 5, 10, 13 grams) plus 6-12 times Example 6, 10, 12 times) decoction and extraction in water for 0.5-2.5 hours (Example 0.5, 1.5, 2.5 hours), extraction 1-4 times (Example 1, 3, 4 times), concentrated to 40-70ml (Example 40, 55, 70ml ), add 45 ~ 65ml (example 45, 55, 65ml) 95% ethanol precipitation, filter, cross AB type, D type macroporous resin column or polyamide resin column, wash column with distilled water ...

Embodiment 2

[0115] Embodiment 2: Fill the liquid after adding the solubilizing agent in Embodiment 1, and then add the propellant into a pressure-resistant container with a special valve system to obtain an aerosol.

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PUM

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Abstract

The invention discloses a preparation method of a quick effective preparation used for preventing and treating chronic obstructive pulmonary disease. The invention has the steps as follows: Salvia miltiorrhiza which is 12 to 20 by weight parts is obtained, entrainer is added, CO 2 super interface extraction is performed, and extract and Salvia miltiorrhiza residue are obtain to be prepared for using; the obtained Salvia miltiorrhiza residue, Rhizoma Fagopyri Cymosi of 5 to 27 by weight parts, liquorice of 2 to 5 by weight parts, bitter almond of 6 to 15 weight parts, Chinese ephedra of 1 to 4 by weight parts, and perilla-seeds of 5 to 13 by weight parts are added with water to be decocted, concentrated, ethanol-precipitated, filtered, resin-absorbed, and ultrasonic-eluted; after being concentrated, collecting solution is mixed with the Salvia miltiorrhiza extract to obtain the quick effective preparation. The preparation method leads the active ingredients to be enriched and concentrated to the utmost extent, and acquires the unexpected effects.

Description

Technical field: [0001] The invention relates to a preparation process of a quick-acting preparation for preventing and treating chronic obstructive pulmonary disease, belonging to the field of traditional Chinese medicine preparations. Background technique: [0002] Chronic obstructive pulmonary disease (COPD, referred to as COPD) is a common chronic respiratory disease. In August 2002, the COPD diagnosis and treatment guideline formulated by the Chinese Medical Association Respiratory Branch Chronic Obstructive Pulmonary Disease Group included It is defined as a disease characterized by airflow limitation and includes chronic bronchitis and emphysema, among others. Such patients suffer from long-term illness and deficiency, qi disease and blood, heart yang is weak, and are easily attacked by exogenous evils; % patients with pulmonary hypertension belong to COPD. The main symptoms of the disease are cough, phlegm, wheezing, wheezing, and shortness of breath when moving. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/12A61K47/34A61P11/00A61K47/26A61K47/44
Inventor 季克胜丁安伟段金廒范欣生张丽梁桃圣
Owner JINGHUA PHARMA GRP
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