Disinfection sterilizing type medical supersonic couplant and method of preparing the same

An ultrasonic coupling agent, disinfection and sterilization technology, which is used in pharmaceutical formulations, preparations for in vivo experiments, etc., to achieve the effect of rapid and long-term sterilization.

Active Publication Date: 2010-07-28
广州市一杰医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to avoid cross-infection during ultrasonic detection of the mucous membrane of the cavity, the probe is often coated with an ultrasonic coupling agent and then covered with a condom for detection. In order to facilitate the insertion of the probe into the cavity, an ultrasonic coupling agent is often applied outside the condom Lubrication method is used for detection, which is extremely cumbersome to operate
The general ultrasonic coupling agent not only fails to meet the requirements of sterility, but also because the method of condom covering the probe has a great impact on the sound wave transmission and image clarity, so the development of a rapid and long-term sterilizing medical ultrasonic coupling agent in the cavity Significant in terms of mucosal detection
At present, when it is used for cavity ultrasound treatment, a disposable jacket is added to the probe. The jacket is expensive, with a charge of 30 to 50 yuan each, and a couplant is used, which also has the problem of cavity ultrasound detection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Prepare according to the following components and weight percentage

[0017] 0.05-0.15% of polyhexamethylene biguanide, 0.1-0.2% of hydroxyethyl cellulose, 1-10% of propylene glycol, and the balance is deionized water.

[0018] Preparation method: disperse hydroxyethyl cellulose in propylene glycol, add enough deionized water to stir and disperse, heat to 75-80°C, keep warm for 30min, wait until the liquid is transparent, cool to 45°C, add polyhexamethylene biguanide, stir and cool , and finally canned.

[0019] Take the preparation of 1000kg of this medical ultrasonic coupling agent as an example, and weigh it according to the following weight

[0020] The concentration is 5kg of 20% polyhexamethylene biguanide, 20kg of hydroxyethyl cellulose, 100kg of propylene glycol, and 875kg of deionized water.

[0021] Preparation method: Disperse 20kg of hydroxyethyl cellulose in 100kg of propylene glycol, add 875kg of deionized water and heat to 80°C to dissolve for 30min, af...

Embodiment 2

[0023] Prepare according to the following components and weight percentage

[0024] 0.01-0.1% of polyhexamethylene biguanide, 0.01-0.1% of chlorhexidine acetate, 0.1-0.2% of hydroxyethyl cellulose, 1-10% of propylene glycol, and the balance is deionized water.

[0025] Preparation method: Under the requirement of 0.05-0.15% of polyhexamethylene biguanide + chlorhexidine acetate, weigh polyhexamethylene biguanide and chlorhexidine acetate within the above ranges respectively. Chlorhexidine acetate, then disperse hydroxyethyl cellulose in propylene glycol, add enough deionized water to stir and disperse, heat to 75-80°C, keep warm for 30min, wait until the liquid is transparent, cool to 45°C, add polyhexamethylene The base biguanide and chlorhexidine acetate are stirred and cooled, and finally canned.

Embodiment 3

[0027] Prepare according to the following components and weight percentage

[0028] 0.01-0.1% of benzalkonium chloride, 0.01-0.1% of chlorhexidine acetate, 0.1-0.2% of hydroxyethyl cellulose, 1-10% of propylene glycol, and the balance is deionized water.

[0029] Preparation method: Disperse hydroxyethyl cellulose in propylene glycol, add enough deionized water to stir and disperse, heat to 75-80°C, keep warm for 30min, wait until the liquid is transparent, cool to 45°C, add benzalkonium chloride and acetate chloride It must be stirred and cooled, and finally canned.

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PUM

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Abstract

The invention discloses a disinfection sterilization medical ultrasonic coupling medium with the bactericidal function and used in the ultrasonic detection and treatment of skin and cavitary mucosa and a preparation method of the coupling medium, wherein, the ultrasonic coupling medium comprises propylene glycol, de-ionized water and one viscosity modifier of the hydroxy ethyl cellulose, carbomerand hydroxy propyl cellulose. The coupling medium further comprises a fungicide of 0.05 to 0.15 percent and the constituents of the fungicide are any one of polyhexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, trichlorobenzene phenoxy diphenyl ether and nanometer silver or any combination of the olyhexamethylene biguanide, the benzalkonium chloride, thebenzalkonium bromide, the chlorhexidine acetate, the trichlorobenzene phenoxy diphenyl etherand, and the nanometer silver; the preparation method used for preparing the ultrasonic coupling medium is as follows: dispersing the hydroxy ethyl cellulose in the propylene glycol, stirring and dispersing the hydroxy ethyl cellulose by adding enough water, heating to 75 to 80 DEG C, preserving the heat for 30 minutes to cool the hydroxy ethyl cellulose and the propylene glycol to 45 DEG C, adding the fungicide to stir and cool the fungicide, the hydroxy ethyl cellulose and the propylene glycol to obtain the filled coupling medium. Tests show that the products of the coupling medium have fast and long sterilization effect and meet the requirements of various related standards.

Description

Technical field [0001] The invention involves medical ultrasound coupling agents, especially for a sterilized sterilized medical ultrasonic coupling method and preparation method for skin and lata mucosal ultrasonic detection and treatment. Background technique [0002] In the existing technical Chinese medicine ultrasound coupling agent, one of the viscosity regulators, propylene glycol solvents, and de -ionic water are mainly prepared by hydroxyetoyte cellulose, caobham, hydroxyl propyl cellulose.This ultrasonic coupling agent is often used for clinical ultrasound diagnosis and treatment, and the coupling effect between the vocal (ultrasonic probe or the treatment head) and the measured objects enters the body smoothly to obtain a reliable image or the tissue of treatment.The basic requirements are to effectively transmit sound waves, and the sound impedance rate is between the sound impedance rate of the sound and the human tissue.Deep, no damage to the sound, easy to apply e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00
Inventor 伍于添
Owner 广州市一杰医药科技有限公司
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