Disinfection sterilizing type medical supersonic couplant and method of preparing the same
An ultrasonic coupling agent, disinfection and sterilization technology, which is used in pharmaceutical formulations, preparations for in vivo experiments, etc., to achieve the effect of rapid and long-term sterilization.
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Embodiment 1
[0016] Prepare according to the following components and weight percentage
[0017] 0.05-0.15% of polyhexamethylene biguanide, 0.1-0.2% of hydroxyethyl cellulose, 1-10% of propylene glycol, and the balance is deionized water.
[0018] Preparation method: disperse hydroxyethyl cellulose in propylene glycol, add enough deionized water to stir and disperse, heat to 75-80°C, keep warm for 30min, wait until the liquid is transparent, cool to 45°C, add polyhexamethylene biguanide, stir and cool , and finally canned.
[0019] Take the preparation of 1000kg of this medical ultrasonic coupling agent as an example, and weigh it according to the following weight
[0020] The concentration is 5kg of 20% polyhexamethylene biguanide, 20kg of hydroxyethyl cellulose, 100kg of propylene glycol, and 875kg of deionized water.
[0021] Preparation method: Disperse 20kg of hydroxyethyl cellulose in 100kg of propylene glycol, add 875kg of deionized water and heat to 80°C to dissolve for 30min, af...
Embodiment 2
[0023] Prepare according to the following components and weight percentage
[0024] 0.01-0.1% of polyhexamethylene biguanide, 0.01-0.1% of chlorhexidine acetate, 0.1-0.2% of hydroxyethyl cellulose, 1-10% of propylene glycol, and the balance is deionized water.
[0025] Preparation method: Under the requirement of 0.05-0.15% of polyhexamethylene biguanide + chlorhexidine acetate, weigh polyhexamethylene biguanide and chlorhexidine acetate within the above ranges respectively. Chlorhexidine acetate, then disperse hydroxyethyl cellulose in propylene glycol, add enough deionized water to stir and disperse, heat to 75-80°C, keep warm for 30min, wait until the liquid is transparent, cool to 45°C, add polyhexamethylene The base biguanide and chlorhexidine acetate are stirred and cooled, and finally canned.
Embodiment 3
[0027] Prepare according to the following components and weight percentage
[0028] 0.01-0.1% of benzalkonium chloride, 0.01-0.1% of chlorhexidine acetate, 0.1-0.2% of hydroxyethyl cellulose, 1-10% of propylene glycol, and the balance is deionized water.
[0029] Preparation method: Disperse hydroxyethyl cellulose in propylene glycol, add enough deionized water to stir and disperse, heat to 75-80°C, keep warm for 30min, wait until the liquid is transparent, cool to 45°C, add benzalkonium chloride and acetate chloride It must be stirred and cooled, and finally canned.
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