Method for preparing meso-porous nano hydroxyl phosphorite crystal

A nano-hydroxyapatite and crystal technology, applied in chemical instruments and methods, prostheses, phosphorus compounds, etc., can solve the problems of low mechanical strength, poor regularity of material structure, restricting application, etc., and achieve large specific surface area, high biological Activity and biocompatibility, effect of perfect crystal development

Inactive Publication Date: 2008-09-03
LANZHOU UNIVERSITY OF TECHNOLOGY
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  • Abstract
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AI Technical Summary

Problems solved by technology

Due to the irregular shape of the macroscopic pores, the obtained material has poor structural regularity and low mechanical strength, which restricts its application.

Method used

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  • Method for preparing meso-porous nano hydroxyl phosphorite crystal

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preparation example Construction

[0013] The present invention is a kind of preparation method of mesoporous nano-hydroxyapatite crystal, and its steps are:

[0014] (1) Take a certain amount of soluble calcium salt and phosphorus pentoxide or phosphoric acid ester by weighing the stoichiometric ratio of Ca / P=1.67;

[0015] (2) dissolving phosphorus pentoxide or phosphoric acid ester in the alcoholic solution, dissolving the soluble calcium salt in the aqueous solution, the volume ratio of the aqueous solution to the alcoholic solution is 2 / 3, or 1, or 3 / 2;

[0016] (3) Mix the above two solutions, adjust the pH value of the mixed solution between 9 and 10 with ammonia water, and stir fully;

[0017] (4) Pour the above solution into a reaction kettle, and carry out a hydrothermal reaction at a temperature of 140° C. to 180° C. for 8 hours to obtain hydroxyapatite precipitation;

[0018] (5) The precipitate was washed with distilled water, filtered with suction, and dried at 200° C. to obtain mesoporous nano-h...

Embodiment 1

[0022] Take a certain amount of calcium nitrate tetrahydrate (Ca(NO) by weighing the stoichiometric ratio of Ca / P=1.67 3 ) 2 4H 2 O) and phosphorus pentoxide (P 2 o 5 ), be dissolved in distilled water and ethanol solution respectively, the volume ratio of aqueous solution and ethanol solution is 2 / 3, adopt ultrasonic shock to dissolve, above-mentioned solution is mixed, adopt magnetic stirrer to stir, pH value is adjusted at 9 with ammonia water, then The above mixed solution was poured into a reaction kettle, hydrothermally reacted at a temperature of 140°C for 8 hours, the precipitate was repeatedly washed with distilled water, suction filtered, and dried at 200°C to obtain mesoporous nano-hydroxyapatite crystals.

[0023] X-ray diffraction results show that the obtained product is a hydroxyapatite crystal with higher purity, and almost no other impurity phases exist; as figure 1 As shown, the nano-hydroxyapatite crystal has a mesoporous structure, the particle size is ...

Embodiment 2

[0025] Weigh a certain amount of Ca(NO) according to the stoichiometric ratio of Ca / P=1.67 3 ) 2 4H 2 O and P 2 o 5 , respectively dissolved in distilled water and propanol solution, the volume ratio of the aqueous solution to the propanol solution is 1, ultrasonically oscillated to dissolve, mix the above solutions, stir with a magnetic stirrer, adjust the pH value to 10 with ammonia water, and then mix the above The solution was poured into a reaction kettle, subjected to hydrothermal reaction at a temperature of 160° C. for 8 hours, the precipitate was repeatedly washed with distilled water, filtered with suction, and dried at 200° C. to obtain mesoporous nano-hydroxyapatite crystals. The result is basically the same as Example 1.

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Abstract

A method for preparing mesoporous hydroxyapatite nanocrystal includes the following steps: weighing soluble calcium salt and phosphorus pentoxide or phosphate ester at a stoichiometric ratio of Ca/P of 1.67; respectively dissolving the phosphorus pentoxide or phosphate ester into the alcohol solution, and dissolving the soluble calcium salt into the aqueous solution, wherein the volume ratio of the aqueous solution/alcohol solution is of 2/3, 1 or 3/2; mixing the two solutions, adjusting the pH value of the mixed solutino to 9-10 with the ammonia water, and intensively mixing; feeding the solution into a reaction kettle, and carrying out the hydrothermal reaction at a temperature of 140-180 DEG C for 8 hours to obtain hydroxyapatite precipitate; washing with the distilled water, vacuum-filtering; and drying at a temperature of 200DEG C to obtain the mesoporous hydroxyapatite nanocrystal.

Description

technical field [0001] The invention relates to a preparation method of hydroxyapatite crystals. Background technique [0002] Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ], referred to as HAP; its composition is close to the inorganic components of biological bone tissue, with good biological activity and biocompatibility. After implanted into the human body, under the action of body fluids, calcium and phosphorus will be released from the surface of the material, absorbed by the body tissue, and form a chemical bond with the human bone tissue to grow new tissue. It is an ideal hard bone tissue replacement material. With people's in-depth understanding of the structure and properties of hydroxyapatite, its application fields are also expanding. Synthetic hydroxyapatite crystals can also be used as fluorescent materials, chromatographic separation agents, catalysts and adsorption agents for biological macromolecules. Drugs or drug carriers used to inhibit the growth of vario...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61L27/12
Inventor 徐惠张斯凡陈泳苟国俊欧玉静翟钧
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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