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Ligustrazine phosphoric acid sustained-release dropping pill and preparation method thereof

A technology of ligustrazine phosphate and sustained-release dropping pills is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., which can solve the problems of difficult operation and great pain for patients, and achieves low labor intensity and simple equipment. , the effect of less process

Inactive Publication Date: 2008-09-24
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, there are also disadvantages that the operation is difficult and the patient suffers a lot.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Based on the total weight of 100g, weigh 30% of the matrix PEG4000, 10% of PEG6000, 33% of stearic acid, and 27% of the raw material ligustrazine phosphonate; it is prepared according to the above method.

[0041] The obtained product has qualified release degree and good roundness.

Embodiment 2

[0043] Based on the total weight of 100g, weigh 40% of the matrix PEG4000, 15% of PEG6000, 35% of stearic acid, and 10% of the raw material ligustrazine phosphonate; it is prepared according to the above method.

[0044] The release degree is qualified and the roundness is good.

Embodiment 3

[0046] Based on the total weight of 100g, weigh 20% of the base polyoxyl (40) stearate, 10% of PEG6000, 43% of glyceryl monostearate, and 27% of the raw material ligustrazine phosphonate; prepared by the above method.

[0047] The obtained product has qualified release degree and good roundness.

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PUM

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Abstract

The invention belongs to the field of ligustrazine phosphate sustained-release pharmaceutical technology, and particularly relates to a sustained-release ligustrazine phosphate dropping pill and the preparation method thereof, and aims to make up for the deficiency of the prior art and provide a sustained-release ligustrazine phosphate dropping pill of high bioavailability, fast effect, steady drug action, long effective hours, low frequency of drug taking, portability and absence of toxic and side effects as well as the preparation method thereof.

Description

[technical field] [0001] The invention belongs to the technical field of ligustrazine phosphate medicinal preparations, and in particular relates to ligustrazine phosphate sustained-release dripping pills and a preparation method thereof. [Background technique] [0002] Ligustrazine is one of the components of Umbelliferae Ligusticum Chuanxiong, which is now a synthetic product. Its hydrochloride or phosphate is commonly used. Because its phosphate is relatively stable and not easy to sublime, it has more advantages than hydrochloride. This product has the effect of anti-platelet aggregation, and has agglomeration effect on the aggregated platelets; it can still expand Small arteries, improve microcirculation and cerebral blood flow, produce antithrombotic and thrombolytic effects. It is suitable for occlusive vascular disease, cerebral thrombosis, vasculitis, coronary heart disease, angina pectoris, etc. For the acute recovery period of ischemic cerebrovascular disease an...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/4965A61P7/02
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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