Cefpodoxime proxetil suspension composition and preparation thereof

Abstract

The invention relates to a cefpodoxime proxetil dry suspension composition and a preparation method thereof. The invention provides the cefpodoxime proxetil dry suspension composition, containing 100parts by weight of the cefpodoxime proxetil and 20 to 500 parts by weight of the glyceryl behenate. The invention also provides the preparation method of the dry suspension composition. The dry suspension composition of the invention is capable of reducing bitterness of the cefpodoxime proxetil remarkably and improving compliance of a clinical patient, thereby being suitable for a child to take adrug.

Description

technical field

[0001] The invention relates to a dry suspension composition and a preparation method thereof, in particular to a cefpodoxime axetil dry suspension composition and a preparation method thereof. Background technique

[0002] Cefpodoxime axetil is an oral broad-spectrum third-generation cephalosporin. After entering the body, it is hydrolyzed into cefpodoxime by non-specific esterase to exert antibacterial effect. It is effective against both Gram-positive and Gram-negative bacteria. It is clinically used for sensitive bacteria upper respiratory tract infection, lower respiratory tract infection, simple urinary tract infection, simple skin and skin soft tissue infection, etc.

[0003] Dry suspension is an important clinical dosage form of cefpodoxime axetil, especially suitable for children and elderly patients. There are two types of cefpodoxime axetil suspensions on the market abroad: liquid suspension and solid dry suspension. Before oral administration, th...

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