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Cefpodoxime proxetil suspension composition and preparation thereof

A technology of cefpodoxime axetil and dry suspension, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, powder delivery, etc., can solve problems such as inability to effectively mask bitterness, reduce patients' compliance with clinical medication, etc. Medication compliance, ease of acceptance, and bitterness-improving effects

Active Publication Date: 2010-06-02
海南三叶美好制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, we have shown through a large number of experiments that cefpodoxime axetil is a drug with a significant bitter taste, and conventional methods such as adding flavors and sweeteners cannot effectively cover up its bitter taste, which makes patients dislike the existing cefpodoxime axetil dry mix. The clinical medication of the suspension produces a sense of resistance, which reduces the patient's compliance with clinical medication

Method used

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  • Cefpodoxime proxetil suspension composition and preparation thereof

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Embodiment 1

[0061] Formulation of dry suspension 1

[0062] Composition of preparation prescription Content of components in each package of dry suspension (mg)

[0063] Cefpodoxime axetil 70mg (equivalent to cefpodoxime 50mg)

[0064] Glyceryl behenate ( 888ATO) 85mg

[0065] Mannitol 1450mg

[0066] Sucrose 800mg

[0067] Sodium carboxymethylcellulose 65mg

[0068] Xanthan Gum 20mg

[0069] Peppermint Flavor 15mg

[0070] Aspartame 15mg

[0071] Micronized silica gel 15mg

[0072] Preparation method: sieve cefpodoxime axetil (Aurobindo Pharma Ltd. India Arabindu company) and 888ATO (French Gattefosse S.A), mix them evenly. The mixture was placed in a constant temperature oven at 80-85°C and heated for 10-15 minutes to make cefpodoxime axetil and 888ATO co-melted. The molten mixture was then cooled to room temperature, followed by crushing and sieving through a 60-mesh sieve. Add sucrose (Guangxi Liuxing Sugar Industry Co., Ltd.), mannitol (Qingdao Mingyue Seaweed Group C...

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Abstract

The invention relates to a cefpodoxime proxetil dry suspension composition and a preparation method thereof. The invention provides the cefpodoxime proxetil dry suspension composition, containing 100parts by weight of the cefpodoxime proxetil and 20 to 500 parts by weight of the glyceryl behenate. The invention also provides the preparation method of the dry suspension composition. The dry suspension composition of the invention is capable of reducing bitterness of the cefpodoxime proxetil remarkably and improving compliance of a clinical patient, thereby being suitable for a child to take adrug.

Description

technical field [0001] The invention relates to a dry suspension composition and a preparation method thereof, in particular to a cefpodoxime axetil dry suspension composition and a preparation method thereof. Background technique [0002] Cefpodoxime axetil is an oral broad-spectrum third-generation cephalosporin. After entering the body, it is hydrolyzed into cefpodoxime by non-specific esterase to exert antibacterial effect. It is effective against both Gram-positive and Gram-negative bacteria. It is clinically used for sensitive bacteria upper respiratory tract infection, lower respiratory tract infection, simple urinary tract infection, simple skin and skin soft tissue infection, etc. [0003] Dry suspension is an important clinical dosage form of cefpodoxime axetil, especially suitable for children and elderly patients. There are two types of cefpodoxime axetil suspensions on the market abroad: liquid suspension and solid dry suspension. Before oral administration, th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K9/14A61P31/04
Inventor 黄合全丹张建军高缘
Owner 海南三叶美好制药有限公司
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